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Pittsburgh Steelers vs. Seattle Seahawks prediction, pick for NFL Week 2 on Sunday 9/14/25

Pittsburgh Steelers vs. Seattle Seahawks prediction, pick for NFL Week 2 on Sunday 9/14/25

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By: Dan Johnson

Seattle’s cross-country road machine against Pittsburgh’s trench-heavy template in a 1:00 a.m. ET kick that doubles as a 10:00 a.m. PT body-clock spot for the visitors. The travel narrative will swirl, but Seattle has been an outlier in the best way—27–11 across its last 38 10 a.m. PT kickoffs (≈71% win rate), a clean 3–0 in those starts last season, and a current run of eight straight Sunday road wins after going 7–1 straight-up away from home a year ago. Expectations of a field-position game more than a wholesale fade of the West-to-East traveler set the tone. Below is my prediction for NFL Week 2’s game between the Pittsburgh Steelers and the Seattle Seahawks.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

Steelers vs. Seahawks prediction, preview

The central landscape is Pittsburgh’s defense versus Seattle’s ability to stay on schedule. In Week 1, the Steelers missed 17 tackles, the most in the league, and allowed successful plays on every first-read pass they faced. They also yielded the third-highest success rate per dropback and a top-five opposing passer rating. That softness pairs with how Seattle attacked: offenses facing the Seahawks targeted running backs on 34% of attempts, second-highest in the league, and quarterback Sam Darnold completed 69.6% with a quick trigger. Wide receiver Jaxon Smith-Njigba handled true WR1 volume and efficiency (nine catches, 124 yards), while running back Zach Charbonnet—sorry, Ken Walker III owners—led the backfield in snaps and red-zone rushes (12 carries, 47 yards and the touchdown). That short-and-intermediate, RB-inclusive plan travels well against an opponent that bled tackles and first-read efficiency.

Pittsburgh’s offense is undeniably more dangerous with wide receiver D.K. Metcalf now in-house—he opened with 4 receptions for 83 yards—and the perimeter matchup is a stress test for Seattle’s corners. The tell is the explosive profile: Steelers wideouts posted 19.4 yards per reception in Week 1, second-best in the league, and Seattle allowed 20.7 yards per reception to wideouts, worst in the league. Still, that Jets game didn’t prove Pittsburgh fixed the run game (2.7 yards per rush), and when the Steelers can’t threaten on the ground, pass protection strain shows. Rodgers was sacked four times, and edge rusher T.J. Watt didn’t record a sack; that imbalance often invites reversion the following week. If Seattle’s front again wins enough early downs, Darnold can stay in manageable situations and keep the pace under control.

Quick note to fold in on Kenneth Walker III: Week 1 usage (40% snaps, 45.4% rushing share, 32% route share, 13% target share) masked his ceiling, but even in a muted role he posted 2.10 yards after contact per attempt versus Zach Charbonnet’s 1.67 and handled two red-zone carries to Charbonnet’s four. A modest bump toward a 55–60% rushing share meaningfully boosts Seattle’s win equity because Pittsburgh’s front just profiled as vulnerable to explosive runs: fourth-highest missed-tackle rate allowed, sixth-most yards before contact per rush, and a bottom-10 stuff rate, with 182 rushing yards surrendered on 39 Jets attempts (4.7 per). If Seattle leans into duo/outside zone and lets Walker press the frontside before cutting, his burst is the cleanest path to flipping early downs, lightening Sam Darnold’s load, and stealing hidden EPA without needing deep shots to land.

Seahawks vs. Steelers pick, best bet

Injuries nudge my lean toward laying the points. Pittsburgh enters without defensive tackle Derrick Harmon and safety DeShon Elliott, with cornerback Joey Porter Jr. managing a hamstring. Seattle’s report carries questionables, but safety Julian Love just stacked eight solo tackles with a sack, and the defense produced two interceptions versus San Francisco. On a thin total near 40, every drive that ends in three rather than seven magnifies the value of +3.

Here’s that classic 10 a.m. PT body-clock spot. The travel narrative cuts the other way for this specific team. Seattle has been an outlier in a good way: 27–11 in its last 38 such kickoffs, 3–0 in these windows last season, and winners of eight straight Sunday road games as part of a 7–1 road record last year. The market likely has already priced the trip; the move from PIT -2 to -3 with a low total is a standard home-field/early-start tax, not some outsized adjustment. And if scripting matters early, Pittsburgh has lost the first quarter in eight straight and the first half in six straight—hardly the profile of a front-running favorite against a club that historically handles early East Coast starts.

Key player levers favor a cover, too. Running back Jaylen Warren led Pittsburgh with 37 rushing yards and the team still managed only 19 first downs; if the Seahawks replicate last week’s 52% rushing success rate stretch and keep Darnold ahead of the sticks, Seattle can nickel-and-dime a defense that just surrendered the league’s highest completion percentage over expectation. Jaxon Smith-Njigba’s short-area dominance pairs with Seattle’s heavy RB target share to stress Pittsburgh’s tackling and underneath zones. Meanwhile, Rodgers tends to distribute and accumulate volume at home—he has recorded 21 or more completions in eight straight home appearances—which supports sustained drives rather than quick, knockout blows, another small edge to the underdog in a field-goal spread.

The matchup still admits selective Pittsburgh spikes—Metcalf versus the outside corners and edge rusher Alex Highsmith against a shuffling Seattle line—yet the broader profile says one-score margin, late possession leverage, and live backdoor. With the total suppressed, the key number looms larger, and the travel angle that often scares bettors has historically belonged to this visiting roster.

As far as props go, I’m slamming JSN’s over receptions. He opened with nine catches for 124 yards and functioned as the primary first-read outlet, exactly where Pittsburgh showed leakage: the Steelers allowed successful plays on 100% of first-read throws and missed 17 tackles, the most in the league last week. Seattle completed nearly 70% of its passes and funneled targets to the short and intermediate windows, and that approach pairs with a travel-tempo game that favors timing routes over deep-shot volatility. With Pittsburgh’s secondary thinned and its pass rush dictating quicker decisions, expect Seattle to live in option routes, slants, and pivots—high-percentage throws that keep Jaxon Smith-Njigba’s volume elevated.

Best bet: Seahawks +3 (-110) at Steelers

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Best prop lean: Jaxon Smith-Njigba o5.5 total receptions (-135)

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Dan Johnson has been an editor, writer, and analyst for DraftKings and DraftKings Network since 2024. He’s previously held editorial posts at The Paris Review, Macmillan Publishers, Bedford/St. Martin’s Press, ASSIGNMENT Magazine, and FantasySixPack. You can find his various editorial work & writing (sports-related and non-) at all of the above.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is thegreatdansby9) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.