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Top DraftKings Pick6 NFL Picks: Most Popular Plays from Week 1

Top DraftKings Pick6 NFL Picks: Most Popular Plays from Week 1

DraftKings Fantasy Advice Pick6

Published:

By: Sam Connon

With NFL action finally kicking off, a handful of players have already endeared themselves to DraftKings Pick6 competitors. Whether the players themselves came in above or below their projected lines, there were winners on all sides.

Every week, we’ll be taking a look at which players and plays helped the most NFL Pick6 lineups. All eyes were on the first Sunday Night Football showdown of the season, so it isn’t a surprise to see a handful of Baltimore Ravens and Buffalo Bills stars at the top of a handful of lists.

Here were the biggest draws and drivers for big-time payouts over the course of Week 1:

  1. Jahmyr Gibbs MORE Rushing + Receiving Touchdowns (INCORRECT)
  2. Derrick Henry MORE Rushing + Receiving Touchdowns (CORRECT)
  3. Derrick Henry MORE Rushing Yards (CORRECT)
  4. Ja’Marr Chase MORE Rushing + Receiving Touchdowns (INCORRECT)
  5. James Cook MORE Rushing Yards (INCORRECT)
  6. Bijan Robinson MORE Rushing + Receiving Touchdowns (CORRECT)
  7. Lamar Jackson MORE Passing Touchdowns (CORRECT)
  8. Amon-Ra St. Brown MORE Receiving Yards (INCORRECT)
  9. Baker Mayfield MORE Passing Yards (INCORRECT)
  10. Bo Nix MORE Passing Yards (INCORRECT)

10 Week 1 NFL Pick6 Picks That Drove the Most Payout

  1. Derrick Henry MORE Rushing Yards
  2. Derrick Henry MORE Rushing + Receiving Touchdowns
  3. Lamar Jackson MORE Passing Touchdowns
  4. Lamar Jackson MORE Rushing Yards
  5. Jakobi Meyers MORE Receptions
  6. Lamar Jackson MORE Rushing + Receiving Touchdowns
  7. Zay Flowers MORE Receiving Yards
  8. Josh Allen MORE Rushing + Receiving Touchdowns
  9. Joe Burrow LESS Pass Attempts
  10. James Cook MORE Rushing + Receiving Touchdowns

10 NFL Players Who Drove the Most Payout in Week 1 on Pick6

  1. Lamar Jackson, QB (BAL)
  2. Derrick Henry, RB (BAL)
  3. Josh Allen, QB (BUF)
  4. James Cook, RB (BUF)
  5. Zay Flowers, WR (BAL)
  6. Khalil Shakir, WR (BUF)
  7. Joe Burrow, QB (CIN)
  8. Baker Mayfield, QB (TB)
  9. Jakobi Meyers, WR (LV)
  10. Keon Coleman, WR (BUF)

Sam Connon
Sam joined DraftKings in 2025 following five years with Sports Illustrated’s “On SI” network. He has covered the UCLA Bruins, New England Patriots, Tampa Bay Rays, MLB, MiLB and NBA, on top of earning awards from the Society of Professional Journalists and College Media Association during his time as a student at UCLA.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.