The 2025 MLB season is in full swing. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this year is Pick6 Fantasy Baseball!
Here are my top Pick6 plays for today’s MLB slate.
Bryan Reynolds More Than 0.5 Hits
Bryan Reynolds is having a bit of a quiet season at the plate, by his standards. He is batting .246 with a .717 OPS. While that is a step down for a guy who made the All-Star Game last year, with a 99 OPS+, he is just about a league-average hitter. However, today, against Miles Mikolas and the Cardinals, Reynolds should thrive. Miles Mikolas has had a disastrous season in St. Louis, with a 5.17 ERA in 2025. Mikolas has struggled to find any kind of form, giving up at least two runs in 13 of his past 15 starts. Reynolds has historically been great against Mikolas, with a .357 career batting average in 42 at-bats. He should keep that good history going in this game and, at the very least, register a base hit.
Ronald Acuna Jr. More Than 1.5 Hits + Runs + RBIs
Ronald Acuna Jr. had had a season derailed by injury, missing a big chunk of time to start 2025, then spending another stint on the IL earlier this month. However, when Acuna is on the field, he is still one of the best hitters in baseball. He has a .301 batting average and a .968 OPS on the season. He has played 12 games since returning from the IL, giving him plenty of time to get back into a groove before this pivotal series against the Phillies. The Braves’ season is likely over, but anytime you’re playing your divisional rival this late in the calendar, you want to win. Acuna has been a pest to Aaron Nola over the years. The two have faced off 62 times, and Acuna has a .436 OBP with four home runs in those meetings. The vibes are bad around the Phillies after getting swept by the Mets, and Acuna should jump on Nola to get over this number.
Alex Bregman More Than 0.5 Singles
Alex Bregman is having a great first season with the Red Sox. He is batting .298 with a .900 OPS and made his third career AL All-Star team. He has been particularly strong against lefties this season, with an absurd .372 batting average. Most of his power has come against righties, though, with 14 of his 16 home runs coming within the split. However, he has been a world-class contact hitter against lefties. The young Orioles southpaw Cade Povich will be in for a tough test against Bregman. Povich has a 5.13 ERA and a 1.43 WHIP on the season. Between Bregman’s amazing contact numbers against lefties and Povich’s struggles on the mound, a single should be no problem for Bregman in this game.
What is DraftKings Pick6?
Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether or not you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.
How to Play
Create a Pick Set
Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.
Enter an Amount
Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.
Sweat Your Picks
When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.
Compete for Prizes
Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.
Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!
Gambling Problem? Call 1-800-GAMBLER. Must be at least 18 years or older. Higher age limits may apply in some states. Eligibility restrictions apply. Valid only in states where DraftKings Pick6 operates. Void where prohibited. For entertainment purposes only. Winning a contest on DraftKings depends on knowledge and exercise of skill. See terms at pick6.draftkings.com.
