The 2025 MLB season is heating up. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this year is Pick6 Fantasy Baseball!
Here are my top Pick6 plays for today’s MLB slate.
Rafael Devers More Than 0.5 Home Runs
After a slow start to the season, Rafael Devers has cemented himself as one of the best hitters in baseball once again. Over the last 30 days, he has been the fourth-highest performing hitter in standard fantasy scoring. During that stretch, Devers is batting .370 with 33 RBIs, more than anyone else in baseball over the past month. Devers is red hot and also has great career numbers against Atlanta’s starter, Spencer Schwellenbach. In his career against Schwellenbach, he is 2-for-5 and both of those hits were home runs. That includes just two weeks ago when these teams faced off and Devers hit a homer off of Schwellenbach. He has a great chance to hit another one today off the right-hander.

Manny Machado More Than 0.5 RBIs
Manny Machado is another player who has been fantastic over the past month. Over the last 30 days, he is batting .355 with an OPS of .993. Machado has recorded an RBI in five of his past seven games. He should be able to keep that hot run of form going against Bailey Falter. Machado has great career numbers against Falter, hitting two home runs in just four career at-bats against the left-hander. The Pirates’ bullpen is in the bottom 10 in baseball in ERA as well, so even if Machado can’t record an RBI against Falter, he will have a good chance against the Pittsburgh bullpen. Falter has been significantly worse on the road this season. In Pittsburgh, he has an ERA of 2.45 compared to his 5.09 ERA on the road. Machado should drive in a run in this game in San Diego.

Salvador Perez More Than 0.5 RBIs
Tarik Skubal has been the best pitcher in baseball dating back to last season. Not many hitters can find success against Skubal, but Salvador Perez has been an exception to that rule. In 33 career at-bats against Skubal, Perez has a .333 batting average and four home runs. That is a .758 career slugging percentage against one of baseball’s best pitchers. Perez is also much more comfortable in Kansas City than he is on the road. He has a 117 tOPS+ at home this season. Left-handed batters stand virtually no chance against Skubal, but right-handers like Perez have been able to have some success this season, especially on the road, where Skubal has been human. Skubal has a 1.83 ERA at home this season, but that ERA is just 3.38 on the road. Perez should be able to drive in a run against the Tigers on Saturday afternoon.

Ketel Marte More Than 0.5 Runs
Ketel Marte had a career year in 2024, finishing third in the NL MVP race. Marte has carried that momentum into this season and has really caught fire over the past couple of weeks. In the last 14 days, Marte is batting .350 and has an OPS of 1.083. He has three home runs in his past ten games and should keep that momentum going into tonight’s game against Washington. The Diamondbacks have also done a great job of getting Marte home when he gets on base. He has scored 18 runs in his past 20 starts and nine runs in his past 10 starts. Washington pitcher Michael Soroka has struggled this season, sporting a 5.61 ERA. He has been even worse against left-handers, allowing a 125 tOPS+ to left-handed batters. Marte should be able to get on base and score a run in this game.

Jose Altuve More Than 1.5 Hits + Runs + RBIs
Jose Altuve had a slow start to the 2025 season, but he has caught fire over the past two weeks. Over the past 14 days, Altuve is slashing .327/.370/.633 with a 1.003 OPS. He has five home runs and eight RBIs over his past 13 games, and he should keep that momentum heading into today’s matchup against Tampa Bay. Altuve has fantastic career numbers against Rays starter Zack Littell. In 10 career at-bats against Littell, Altuve has six hits. Between his hot streak over the past couple of weeks and his career success against Littell, he should have a productive afternoon in Houston and get over this number.

Ronald Acuna Jr. Less Than 1.5 Total Bases
Ronald Acuna Jr. has had a strong return to the baseball world after missing the start of the season recovering from his ACL injury. However, after hitting two home runs in his first two games, things have slightly cooled off for Acuna. Over the past four games, Acuna has just one extra-base hit, proving that he is still mortal. Things should be very difficult for Acuna today against Walker Buehler. In his career against Buehler, Acuna is just 1-for-12 with five strikeouts and no walks. Buehler has always been able to get the better of Acuna and he should keep that going today. After a shaky start to the season, Buehler has found his form once again. Over his past six starts, Buehler has a 2.56 ERA and has been incredibly consistent. He should be able to hold Acuna under 1.5 total bases in this game.

What is DraftKings Pick6?
Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of two or more players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.
How to Play DraftKings Pick6
Create a Pick Set
Create a Pick Set by choosing two or more players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you cannot pick the same player twice and you must pick players from at least two different teams.
Enter an Amount
Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.
Sweat Your Picks
When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.
Compete for Prizes
Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.
Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!