The NFL schedule has been released, and with it, the odds for each game of the season. Below, you’ll find the full schedule for Week 1 of the upcoming NFL season, with the odds for each week provided by the DraftKings Sportsbook.
All lines for the 2025 NFL season can be found on the DraftKings Sportsbook
2025 NFL Week 1 Schedule
All times in EST
Eagles vs. Cowboys
- Date, Time: Thursday, September 4th, 8:20 p.m.
- Spread: Eagles -7
- Total: o/u 46.5
Chargers vs. Chiefs (Sao Paulo, Brazil)
- Date, Time: Friday, September 5th, 8:00 p.m.
- Spread: Chiefs -3
- Total: o/u 44.5
Browns vs. Bengals
- Date, Time: Sunday, September 7th, 1:00 p.m.
- Spread: Bengals -4.5
- Total: o/u 44.5
Commanders vs. Giants
- Date, Time: Sunday, September 7th, 1:00 p.m.
- Spread: Commanders -7.5
- Total: o/u 45.5
Saints vs. Cardinals
- Date, Time: Sunday, September 7th, 1:00 p.m.
- Spread: Cardinals -3.5
- Total: o/u 43.5
Patriots vs. Raiders
- Date, Time: Sunday, September 7th, 1:00 p.m.
- Spread: Patriots -3.5
- Total: o/u 43.5
Falcons vs. Buccaneers
- Date, Time: Sunday, September 7th, 1:00 p.m.
- Spread: Buccaneers -2.5
- Total: o/u 47.5
Jaguars vs. Panthers
- Date, Time: Sunday, September 7th, 1:00 p.m.
- Spread: Jaguars -3.5
- Total: o/u 45.5
Jets vs. Steelers
- Date, Time: Sunday, September 7th, 1:00 p.m.
- Spread: Steelers -2.5
- Total: o/u 39.5
Colts vs. Dolphins
- Date, Time: Sunday, September 7th, 1:00 p.m.
- Spread: Colts -1.5
- Total: o/u 45.5
Broncos vs. Titans
- Date, Time: Sunday, September 7th, 4:05 p.m.
- Spread: Broncos -7.5
- Total: o/u 43.5
Seahawks vs. 49ers
- Date, Time, Location: Sunday, September 7th, 4:05 p.m.
- Spread: 49ers -1.5
- Total: o/u 45.5
Packers vs. Lions
- Date, Time: Sunday, September 7th, 4:25 p.m.
- Spread: Packers -0.5
- Total: o/u 48.5
Rams vs. Texans
- Date, Time: Sunday, September 7th, 4:25 p.m.
- Spread: Rams -3
- Total: o/u 44.5
Bills vs. Ravens
- Date, Time: Sunday, September 7th, 8:20 p.m.
- Spread: Bills -1.5
- Total: o/u 51.5
Bears vs. Vikings
- Date, Time: Monday, September 8th, 8:15 p.m.
- Spread: Bears -1.5
- Total: o/u 45.5
