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2025 Los Angeles Chargers schedule, odds and lines on DraftKings Sportsbook

2025 Los Angeles Chargers schedule, odds and lines on DraftKings Sportsbook

Updated:

By: Dan Johnson

It’s unfortunate the NFL cultural triumph that was the first-year-Harbaugh Los Angeles Chargers can be reduced to a single stat for a single game: four interceptions for Justin Herbert against the Houston Texans. It was an inexcusable performance for a player not just of Herbert’s pedigree but also his expectations, and it was just as staggering to watch an individual performance self-destruct an entire team that’d spent the entire year establishing themselves as a formidable unit. Herbert, quite literally, threw the season away.

Their run game wasn’t as strong as Harbaugh wanted it to be in 2024, so they went out and signed FA Najee Harris and drafted rookie RB Omarion Hampton out of North Carolina. This is some serious thunder behind an offensive line that saw 2024 first-round pick, Joe Alt, anchor Justin Herbert’s left side. They also added beefy G Mekhi Becton to improve the interior.

Ladd McConkey still doesn’t have much contested-catch-receiver help outside of rookie WR Tre Harris out of Ole Miss, but they likely didn’t upgrade enough at tight end: Tyler Conklin and fifth-round draft pick Oronde Gadsen II aren’t likely to be the difference-makers.

The Chargers seem satisfied with their defense, as they only drafted one EDGE (Kyle Kennard) and otherwise made some mezza-mezza defensive front signings. A lot has to go right for this team to take all these pieces and make a deep playoff run, but if anyone can lead them to it, Harbaugh can. He’s the quarterback whisperer. Herbert bounceback year.

Below, you’ll find the Chargers’ full schedule for the upcoming 2025 season with spreads for each week provided by the DraftKings Sportsbook.


All lines for the 2025 NFL season can be found on DraftKings Sportsbook.


2025 Los Angeles Chargers Odds

Early futures action below! Siren emoji! The Chargers’ Super Bowl odds and win total below, as well as a couple of other team futures available to bet on DraftKings Sportsbook.

Super Bowl: +2800

Conference: +1300

Division: +310

Over 9.5 Wins: -110

2025 Los Angeles Chargers Schedule

We’ll update each of these games with odds and lines as they become available on DraftKings Sportsbook.

Week 1: Chargers (+3) vs. Chiefs (Sao Paolo, Brazil)

Week 2: Chargers (-3) at Raiders

Week 3: Chargers (-1.5) vs. Broncos

Week 4: Chargers (-3.5) at Giants

Week 5: Chargers (-1.5) vs. Commanders

Week 6: Chargers (-1.5) at Dolphins

Week 7: Chargers (-6) vs. Colts

Week 8: Chargers (-3) vs. Vikings

Week 9: Chargers (+4.5) at Titans

Week 10: Chargers (-4.5) vs. Steelers

Week 11: Chargers (-1.5) at Jaguars

Week 12: BYE

Week 13: Chargers (-6.5) vs. Raiders

Week 14: Chargers (+2.5) vs. Eagles

Week 15: Chargers (+4.5) at Chiefs

Week 16: Chargers (-1.5) at Cowboys

Week 17: Chargers (-3.5) vs. Texans

Week 18: Chargers (+2.5) at Broncos

Dan Johnson has been an editor, writer, and analyst for DraftKings and DraftKings Network since 2024. He’s previously held editorial posts at The Paris Review, Macmillan Publishers, Bedford/St. Martin’s Press, ASSIGNMENT Magazine, and FantasySixPack. You can find his various editorial work & writing (sports-related and non-) at all of the above.
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I am a promoter at DraftKings and am also an avid fan and user (my username is thegreatdansby9) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.