UPDATE: McCaffrey will be placed on IR and is expected to miss six weeks, per Kyle Shanahan. Additionally, backup running back Jordan Mason will be placed on IR with a high ankle sprain. This leaves Isaac Guerendo as the 49ers’ top back and he will be a must-add off the waiver wire this week.
UPDATE: Kyle Shanahan announced after the game that McCaffrey suffered a PCL injury, which could end his season.

UPDATE: McCaffrey will not return to Sunday’s game.
UPDATE: McCaffrey’s injury is officially designated as a knee injury and he’s questionable to return. Earlier in the game, he hit is right knee hard on the field after a tackle.
Early in the second quarter of Sunday night’s game against the Buffalo Bills, Christian McCaffrey took a toss and headed to the right sideline. As soon as he tried to accelerate, he shut it down and slid to the ground. He was able to jog off the field on his own power, but headed to the tent and is now in the locker room.

Prior to exiting, McCaffrey rushed seven times for 53 yards and caught two of three targets for 14 yards.
Jordan Mason should now see the bulk of the carries for as long as McCaffrey is out.
The Crown Is Yours: Sign up for DraftKings and experience the ultimate host for games and betting experiences!
All odds provided by DraftKings Sportsbook and all odds subject to change.
I am a promoter at DraftKings and am also an avid fan and user (my username is sontzu) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.