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Three must-start NBA DFS picks for Wednesday 11/4/26

Three must-start NBA DFS picks for Wednesday 11/4/26

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By: Garion Thorne

After a silent night in the NBA on Tuesday, the league comes back with (almost) full-force on Wednesday.

28 of the 30 teams will be in action, and DraftKings’ featured slate is an 11-game behemoth. Let’s sort through the madness and find three picks that you should be building your lineups around this evening.

Set your DraftKings NBA DFS lineups here: NBA $333K Zone Special [$100K to 1st]

PF/C Karl-Anthony Towns, New York Knicks vs. Chicago Bulls, $8,300

I just don’t think the Bulls have the interior size to be able to handle Towns. There’s a chance that Nic Claxton ($5,800; hamstring) is available to make his 2026-27 debut this evening, but even then, the veteran would almost surely be on a minutes restriction. Let’s put it this way: Teams with actual depth at center have been having a hard time containing Towns in the paint this season. Not only is the former No. 1 overall pick averaging 20.3 points per game with a career-best 55.1% field goal rate, but he’s doing so while collecting 13.9 rebounds per contest and while leading the NBA in defensive rebounding rate (37.2%). Understandably, given its roster limitations and commitment to an uptempo pace, Chicago has conceded the second-most opponent rebounds per game in the opening weeks of the season (47.9). I’d say an eighth-straight double-double is a lock for Towns on Wednesday, and he might flirt with another 20-rebound performance.

PG/SG Andrew Nembhard, Indiana Pacers at Memphis Grizzlies, $7,400

Nembhard’s price tag continues to rise in the absence of Tyrese Haliburton (hamstring), yet it still doesn’t feel quite high enough. In the three games Nembhard has played since his teammate’s injury, the 26-year-old is averaging 21.0 points, 9.0 assists and 39.2 FPTS. For 2026-27 as a whole, Nembhard’s also seen his usage rate jump from 16.5% when sharing the floor with Haliburton, to a massive 29.7% with the former All-Star on the bench. It’s a sample where Nembhard is producing 21.8 points and 10.1 assists per 36 — which pretty much exactly aligns with what we’ve seen the past week. The Grizzlies have ridden a stout defense to a 6-1 record, but I think Nembhard is viable even in a tough spot on the slate.

PG/SG Jrue Holiday, Portland Trail Blazers at Phoenix Suns, $5,700

18 years into his NBA career, and playing primarily off the bench for the first time in a decade, it appears that Jrue Holiday still has the juice. I have my doubts that the 36-year-old will be able to maintain a 66.9% true shooting rate over the whole of the season, but at the moment, Holiday is red-hot and contributing across all categories. To wit, on top of his 13.2 points per game, Holiday is registering 4.8 assists, 4.7 rebounds and 1.2 steals. He’s also got a lot of opportunity to play, despite his status as a sixth man, as Ja Morant (hamstring) is sidelined and Damian Lillard ($7,500) is clearly having his minutes monitored. In a matchup against a Suns squad that sits dead-last in defensive rating (124.0), and with a salary well below $6,000, Holiday is a malleable mid-tier asset that can make a lot of other high-end pieces fit in your lineups.

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Garion is a Toronto-based writer who has been playing fantasy sports since elementary school. With a particular affinity for advanced statistics and sabermetrics, he’s been covering DFS Baseball, Football and Basketball for DraftKings dating back to 2018. Prior to that, Garion’s work could be found at FNTSY, SportsGrid, HoopsHype, The New York Daily News and Sportsnet.ca. Still, he is a Dolphins fan, so his decision-making can be questioned from time-to-time.
Disclaimer

All views expressed are my own. I am an employee of DraftKings and am ineligible to play in public DFS or DKSB contests.

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