A pivotal matchup is on tap this afternoon in the Meadowlands. The Cardinals (1-2), despite their sub-.500 record, have impressed this season. Despite fears the team would be uncompetitive, Arizona has hung tough with teams such as the Chargers and 49ers. As for the Giants (2-1), three weeks have felt like an eternity. Injuries to several key players, including quarterback Jaxson Dart, have depleted New York’s roster. Still, there remains plenty of talented pieces taking the field for Big Blue. Which names are poised to step up during this weekend’s NFC clash?
Arizona is a 2.5-point favorite with -142 moneyline odds on DraftKings Sportsbook. New York is a +120 underdog, with the game total set at O/U 44.5 points.
Let’s dive into the top player prop bets for Sunday’s showdown between the Cardinals and Giants.
Cardinals vs. Giants NFL Player Prop Bets for Week 4
Trey McBride 7+ receptions (-142)
Is this a bit pricey for a whopping seven receptions? Maybe, but I’m willing to pay up anyways. After all, Trey McBride is one of the NFL’s premier tight ends. He’s been on an absolute tear in 2026, notching 26 catches for 211 yards and two touchdowns. Even more impressive, he’s hauled in at least eight receptions in each of his three appearances. Dating back to last season, it’s safe to say the All-Pro has a strong bond with quarterback Jacoby Brissett. Speaking of which, Arizona’s quarterback has been a pleasant surprise so far. As a unit, the Cardinals are averaging a respectable 21.0 points and 303.0 yards per game.
Despite a stellar showing last weekend, this Giants defense is a bit of a paper tiger. They’re only 27th in football with a 0.08 EPA per play. To make matters worse, edge rusher Brian Burns (knee) is out for the season. The secondary has been a major issue for head coach John Harbaugh. An already middling group of cornerbacks will be without Paulson Adebo (knee) and potentially Deonte Banks (calf). Rookie linebacker Arvell Reese possesses immense talent, but McBride presents a challenge. Brissett ranks sixth in the NFL in average time to throw (2.62). It’s clear that this Arizona offense prefers quick strikes rather than explosive plays downfield. Keeping that in mind, there should be several opportunities for McBride ton contribute on Sunday.
Malik Nabers 56+ receiving yards (-113)
It’s been a difficult start of the season to say the least for Malik Nabers. Through three games, the wide receiver has recorded just 12 catches for 96 yards. Still, some rust was to be expected. The former LSU standout is recovering from a torn ACL and meniscus that prematurely ended his 2025 campaign. Unfortunately for New York, Dart’s absence caps the ceiling for this passing game. Quarterback Jameis Winston has struggled through two games, looking like a shell of his usual gunslinging self. In fairness, this was about the worst possible scenario for a backup called into duty. During Week 2, Winston matched up against a tenacious Rams defense on the road. Last Sunday, he took the field against Tennessee in the midst of a massive storm.
In theory, Week 4 should be much kinder to this Giants passing game. The Cardinals aren’t very impressive on defense, especially in their secondary. They’re giving up 8.8 yards per pass attempt this season, second-worst in the NFL. Arizona has coughed up 503 yards to opposing wide receivers as well, 12th-most in the league. Keep in mind, this group has been trailing for most of the past two weeks. If the game scripts were a bit different, teams would be more willing to air it out. Nabers, even at less than 100%, is capable of putting up monster numbers. He’s surpassed this total in 16 of his 22 career outings, often in spite of mediocre signal callers. This is the perfect buy-low spot for one of the sport’s elite pass catchers.
