Sunday afternoon’s loaded NFL Week 3 slate features an AFC showdown between the Los Angeles Chargers and the Buffalo Bills at Highmark Stadium, with kickoff set for 1 p.m. ET.
The Chargers (0–2, 4th AFC West) have gotten off to a miserable start, falling to both the Arizona Cardinals and the Las Vegas Raiders. The Bills (2–0, 1st AFC East) look like a Super Bowl contender, plowing past the Houston Texans and the Detroit Lions.
Buffalo is a seven-point home favorite with -340 moneyline odds on DraftKings Sportsbook. Los Angeles is a +270 underdog, with the game total set at O/U 49.5 points.
Let’s dive into the top player prop bets for Sunday’s clash between the Chargers and the Bills.
Chargers vs. Bills NFL Player Prop Bets for Week 3
Josh Allen 250+ Pass Yards (+113)
Josh Allen has his eyes on his second NFL MVP award, with +280 odds on DraftKings Sportsbook. The superstar quarterback has completed 66.7 percent of his passes for 582 yards and five touchdowns while throwing zero interceptions — along with four rushing scores — to push the Bills to 2–0.
Allen, 30, opened his season with 334 passing yards against the Texans before finishing with 248 in Buffalo’s home opener against the Lions. The Wyoming product now has a favorable matchup against the Chargers — widely considered the NFL’s most disappointing team early in the 2026 campaign. Los Angeles has already hemorrhaged 250+ passing yards to both Arizona’s Jacoby Brissett and Las Vegas’ Kirk Cousins — neither of whom are in the same stratosphere as the best QB in football.
Omarion Hampton Anytime Touchdown (-130)
Omarion Hampton has been one of the few sources of offense for the Chargers early on. The 2025 first-rounder, 23, has handled 35 carries for 137 yards so far and found the end zone in both of LA’s previous matchups.
Although the Bills’ undefeated record may not show it, their defense is already showing cracks — particularly against opposing running backs. Houston’s David Montgomery finished with two rushing touchdowns and a receiving score in Week 1, and Detroit’s Jahmyr Gibbs hauled in a touchdown reception in Week 2. After getting more involved in the passing game last week — corralling both targets for 21 yards — Hampton could have multiple ways to hit paydirt for the third time this season.
