The Premier League returns for Matchweek 4 with a full slate of games from Saturday, September 12 through Monday. The headliner is Sunday’s Manchester derby at Old Trafford between City and United, while Arsenal, Chelsea and Liverpool are all favored in their respective fixtures. Below are the top Premier League picks and predictions for Matchweek 4.
Premier League Matchweek 4 Predictions, Picks
| Premier League Match | Prediction |
| Liverpool vs. Fulham | Liverpool Win 2-1 |
| Crystal Palace vs. Ipswich Town | Crystal Palace Win 2-1 |
| Bournemouth vs. Brentford | 2-2 Draw |
| Aston Villa vs. Nottingham Forest | 2-2 Draw |
| Chelsea vs. Hull | Chelsea Win 3-0 |
| Tottenham vs. Everton | Tottenham Win 2-1 |
| Sunderland vs. Arsenal | Arsenal Win 1-0 |
| Coventry vs. Brighton | Brighton Win 2-0 |
| Manchester United vs. Manchester City | Manchester City 3-1 |
| Leeds vs. Newcastle | 1-1 Draw |
Chelsea vs. Hull City Prediction: Chelsea Win 3-0
Maybe all it took was the right manager coming in. Maybe this team just needed an improved (and healthy) midfield. Whatever it is, Chelsea seem to have finally turned the corner. One of the most talented teams in the Premier League, the Blues are flying to start the 2026/27 campaign. They’re tied for the most goals scored (eight) over three weeks, and I expect another high-scoring affair in a dominant win over an inferior side Hull City.
Chelsea vs. Hull City Best Bet: Chelsea -1.5 (-160)
Liverpool vs. Fulham: Liverpool Win 2-1
Fulham have been on the verge of points on three occasions this season, and every time they’ve come up just short. I expect nothing to change this time around. Liverpool haven’t been particularly convincing to open the year, so both teams could find the back of the net in this contest, but the Reds should have enough firepower to sneak out a tight win.
Liverpool vs. Fulham Best Bet: Liverpool ML + Over 2.5 Goals Same Game Parlay (-125)
Sunderland vs. Arsenal: Arsenal Win 1-0
Arsenal have simultaneously looked far superior than they did in their Premier League winning campaign, while also clearly being due to drop points in the near future. That could happen against Sunderland, who have looked quite tough thus far. I give the slight edge to the Gunners, but the overarching theme for this match is there won’t be a lot of goals. Arsenal and Sunderland have combined for just 12 total goals scored and allowed across three matchweeks. This is going to be a tight, grind-it-out affair.
Sunderland vs. Arsenal Best Bet: Under 2.5 Goals (-130)
Manchester United vs. Manchester City: Manchester City Win 3-1
The featured duel of Matchweek 4 is of course the Manchester derby. After a shaky victory in their season opener, City have looked miles better under Enzo Maresca over the last few weeks. This is a team that has the talent to compete with Arsenal for the Premier League title, and they look ready to do so. United, on the other hand, have stumbled out of the gates, securing just four points across three outings. This game will be in Old Trafford, but I expect the superior squad to make a statement and remain perfect across four contests.
Manchester United vs. Manchester City Best Bet: Manchester City ML (+115)
Premier League Matchweek 4 FAQ
When does Premier League Matchweek 4 start?
Premier League Matchweek 4 kicks off on Saturday, September 12 with multiple matches starting at 10:00 A.M. ET / 3:00 P.M. BST.
What are the best Premier League bets for Matchweek 4?
Chelsea -1.5 vs. Hull City, Manchester City ML vs. Manchester United and Sunderland vs. Arsenal Under 2.5 Goals are some of my best bets for Premier League Matchweek 4.
Who is predicted to win the Manchester derby?
Manchester City are favored to beat Manchester United at Old Trafford. City have started the league season in better form and should benefit from having more rest heading into Sunday’s match.
