MLB Betting Splits and Odds for Wednesday, September 2

Looking for today’s MLB betting splits and odds? Below you’ll find the latest DraftKings Sportsbook Moneyline, Run Line and total betting percentages for every game on Wednesday’s slate, plus where the public and sharp money are landing before first pitch.

Today’s MLB Slate

Game	Time (ET)	Moneyline	Total
Padres @ Reds	12:40 PM	CIN +130 / SD -157	O/U 9.5
Braves @ Nationals	1:05 PM	WSH +135 / ATL -163	O/U 9
Athletics @ Rangers	2:35 PM	TEX -167 / ATH +138	O/U 8
Orioles @ Rockies	3:10 PM	COL +138 / BAL -167	O/U 11
Phillies @ Diamondbacks	3:40 PM	AZ -102 / PHI -118	O/U 9
Mariners @ Red Sox	4:10 PM	BOS -137 / SEA +114	O/U 8.5
Blue Jays @ Guardians	6:40 PM	CLE +109 / TOR -131	O/U 7
Giants @ Pirates	6:40 PM	PIT -156 / SF +129	O/U 8.5
Mets @ Rays	6:40 PM	TB -181 / NYM +149	O/U 8
Brewers @ Cubs	7:40 PM	CHC +134 / MIL -162	O/U 8.5
Marlins @ Royals	7:40 PM	KC -112 / MIA -108	O/U 9
Tigers @ Twins	7:40 PM	MIN -118 / DET -102	O/U 8.5
White Sox @ Astros	8:10 PM	HOU -142 / CWS +118	O/U 8.5
Yankees @ Angels	9:38 PM	LAA +141 / NYY -171	O/U 7
Cardinals @ Dodgers	10:10 PM	LAD -258 / STL +208	O/U 8

Best Bets for Wednesday’s MLB Slate

Arizona Diamondbacks ML (-102): Sharp money is hammering AZ, with 92% of handle on just 38% of bets. Taylor Clarke’s 2.60 ERA and 0.882 WHIP tower over Andrew Painter’s 5.95 ERA, and the Diamondbacks just activated Ketel Marte and Lourdes Gurriel Jr.
Dylan Cease Over 6.5 Strikeouts (+111): Cease has cleared this line in 10 of his last 10 starts. His 36.1 K% is among the best in baseball, and Joey Cantillo’s 1.452 WHIP suggests baserunners that extend at-bats.
Detroit Tigers ML (-102): A near pick’em where 99% of handle backs Detroit on just 48% of bets. Riley Greene returns from the IL, and Anderson’s 3.87 ERA gives the Tigers a slight pitching edge over Kremer (4.39 ERA).
Miami Marlins -1.5 (+151): The widest Run Line split on the slate, with 86% of handle on just 7% of bets. Eury Perez (3.44 ERA, 26.8 K%) has a clear advantage over Noah Cameron (3.98 ERA, 21.0 K%).

Padres at Reds Odds and Splits

Market	Home (CIN)	Away (SD)	Bets %	Handle %
Moneyline	+130	-157	22% / 78%	4% / 96%
Run Line	+1.5 (-125)	-1.5 (+103)	52% / 48%	22% / 78%
Total	Over 9.5 (+101)	Under 9.5 (-121)	40% / 60%	11% / 89%

Pitching Matchup

Stat	Brandon Williamson (CIN)	Casey Mize (SD)
Record	2-3	1-2
ERA	6.11	6.26
WHIP	1.643	1.522
K%	14.8%	10.5%
HR/9	1.29	2.35

Sharp money is pounding the Under at 89% of handle despite both pitchers carrying ERAs above 6.00. Williamson is making his first start since returning from the 60-day IL, and Mize has allowed 2.35 home runs per nine innings across five starts.

Braves at Nationals Odds and Splits

Market	Home (WSH)	Away (ATL)	Bets %	Handle %
Moneyline	+135	-163	21% / 79%	1% / 99%
Run Line	+1.5 (-120)	-1.5 (-101)	35% / 65%	6% / 94%
Total	Over 9 (-121)	Under 9 (+101)	67% / 33%	86% / 14%

Pitching Matchup

Stat	Brad Lord (WSH)	Grant Holmes (ATL)
Record	5-2	9-5
ERA	3.75	3.71
WHIP	1.191	1.337
K%	21.5%	18.7%
HR/9	1.03	1.33

Atlanta’s NL East lead shows in the splits, with 99% of handle on its Moneyline and 94% on the Run Line. The Over is drawing 86% of handle, suggesting sharp bettors expect these two mid-3.00 ERA starters to allow enough traffic for a high-scoring game.

Athletics at Rangers Odds and Splits

Market	Home (TEX)	Away (ATH)	Bets %	Handle %
Moneyline	-167	+138	80% / 20%	53% / 47%
Run Line	-1.5 (+130)	+1.5 (-157)	53% / 47%	7% / 93%
Total	Over 8 (-102)	Under 8 (-118)	86% / 14%	97% / 3%

Pitching Matchup

Stat	Cody Bradford (TEX)	Jacob Lopez (ATH)
Record	0-3	5-4
ERA	3.42	4.82
WHIP	1.519	1.465
K%	11.4%	21.8%
HR/9	0.34	1.36

Sharp money is loading the A’s Run Line at 93% of handle vs. 47% of bets, suggesting the 53-86 Athletics can keep this close despite Texas being a clear Moneyline favorite. The Over also carries 97% of handle behind two pitchers with WHIPs above 1.460.

Orioles at Rockies Odds and Splits

Market	Home (COL)	Away (BAL)	Bets %	Handle %
Moneyline	+138	-167	19% / 81%	10% / 90%
Run Line	+1.5 (-112)	-1.5 (-107)	35% / 65%	3% / 97%
Total	Over 11 (-120)	Under 11 (+100)	44% / 56%	62% / 38%

Pitching Matchup

Stat	Tomoyuki Sugano (COL)	Trevor Rogers (BAL)
Record	12-8	9-9
ERA	5.23	4.38
WHIP	1.361	1.249
K%	13.9%	20.9%
HR/9	1.93	1.05

Coors Field drives the 11-run total, the highest on the slate. Baltimore’s Run Line holds 97% of handle vs. 65% of bets. Sugano’s 1.93 HR/9 at altitude is a significant concern, while Rogers brings a lower ERA and better strikeout rate to the thinner air.

Phillies at Diamondbacks Odds and Splits

Market	Home (AZ)	Away (PHI)	Bets %	Handle %
Moneyline	-102	-118	38% / 62%	92% / 8%
Run Line	+1.5 (-162)	-1.5 (+134)	63% / 38%	97% / 3%
Total	Over 9 (-119)	Under 9 (-101)	42% / 58%	73% / 27%

Pitching Matchup

Stat	Taylor Clarke (AZ)	Andrew Painter (PHI)
Record	2-3	3-8
ERA	2.60	5.95
WHIP	0.882	1.444
K%	15.5%	19.7%
HR/9	0.87	1.56

The biggest sharp-public split on the Moneyline: 92% of handle backs Arizona on just 38% of bets. Clarke’s 2.60 ERA and sub-0.900 WHIP stand in stark contrast to Painter’s 5.95 ERA. The Diamondbacks also activated Ketel Marte and Lourdes Gurriel Jr. this week, strengthening a lineup that was already trending upward.

Mariners at Red Sox Odds and Splits

Market	Home (BOS)	Away (SEA)	Bets %	Handle %
Moneyline	-137	+114	84% / 16%	76% / 24%
Run Line	-1.5 (+153)	+1.5 (-186)	75% / 25%	31% / 69%
Total	Over 8.5 (-108)	Under 8.5 (-112)	85% / 15%	50% / 50%

Pitching Matchup

Stat	Patrick Sandoval (BOS)	Bryce Miller (SEA)
Record	1-3	4-8
ERA	4.20	4.12
WHIP	1.711	1.085
K%	23.2%	24.5%
HR/9	1.20	1.63

Sharp money favors Seattle’s Run Line at 69% of handle vs. 25% of bets, a notable lean against the public. The total’s handle is split evenly despite 85% of bets landing on the Over. Sandoval’s 1.711 WHIP is the highest among all starters on Wednesday’s slate.

Blue Jays at Guardians Odds and Splits

Market	Home (CLE)	Away (TOR)	Bets %	Handle %
Moneyline	+109	-131	25% / 75%	8% / 92%
Run Line	+1.5 (-164)	-1.5 (+136)	74% / 26%	1% / 99%
Total	Over 7 (-122)	Under 7 (+101)	82% / 18%	44% / 56%

Pitching Matchup

Stat	Joey Cantillo (CLE)	Dylan Cease (TOR)
Record	9-7	9-5
ERA	3.70	2.34
WHIP	1.452	1.051
K%	24.6%	36.1%
HR/9	0.99	0.60

Toronto’s Run Line carries the most extreme split of any market on the slate: 99% of handle on just 26% of bets. Cease’s 2.34 ERA and 36.1 K% make him one of the most dominant pitchers in baseball, and the Under is drawing 56% of handle despite only 18% of bets.

Giants at Pirates Odds and Splits

Market	Home (PIT)	Away (SF)	Bets %	Handle %
Moneyline	-156	+129	67% / 33%	71% / 29%
Run Line	-1.5 (+136)	+1.5 (-164)	42% / 58%	97% / 3%
Total	Over 8.5 (-120)	Under 8.5 (+100)	53% / 47%	56% / 44%

Pitching Matchup

Stat	Jared Jones (PIT)	Landen Roupp (SF)
Record	2-6	8-13
ERA	4.83	4.25
WHIP	1.280	1.310
K%	26.6%	22.4%
HR/9	1.49	0.71

Pittsburgh’s Run Line is drawing 97% of handle on 42% of bets, a strong sharp lean on the home favorite to cover. Jones has struck out batters at a 26.6% clip, but his 1.49 HR/9 creates volatility. San Francisco enters at 57-82, the worst record on the slate.

Mets at Rays Odds and Splits

Market	Home (TB)	Away (NYM)	Bets %	Handle %
Moneyline	-181	+149	85% / 15%	45% / 55%
Run Line	-1.5 (+119)	+1.5 (-143)	51% / 49%	3% / 97%
Total	Over 8 (-110)	Under 8 (-110)	67% / 33%	99% / 1%

Pitching Matchup

Stat	Griffin Jax (TB)	Justin Hagenman (NYM)
Record	6-9	0-0
ERA	3.63	—
WHIP	1.211	—
K%	26.4%	—
HR/9	1.38	—

Hagenman returns from the 60-day IL (rib) to make his first start of 2026, creating significant uncertainty for this matchup. Sharp money is on the Mets at 55% of handle vs. 15% of bets, a notable contrarian lean against the AL East leaders. New York’s Run Line holds 97% of handle, and the Over sits at a staggering 99%. The Mets also recently activated Juan Soto and Mark Vientos.

Brewers at Cubs Odds and Splits

Market	Home (CHC)	Away (MIL)	Bets %	Handle %
Moneyline	+134	-162	18% / 82%	2% / 98%
Run Line	+1.5 (-126)	-1.5 (+105)	38% / 62%	0% / 100%
Total	Over 8.5 (-103)	Under 8.5 (-117)	37% / 63%	12% / 88%

Pitching Matchup

Stat	David Peterson (CHC)	Jacob Misiorowski (MIL)
Record	4-1	14-5
ERA	3.90	1.73
WHIP	1.355	0.755
K%	19.4%	38.9%
HR/9	1.14	0.78

Milwaukee’s Run Line commands 100% of handle, the only market on the entire slate at that mark. Misiorowski’s 1.73 ERA, 0.755 WHIP and 38.9 K% make him the most dominant starter on Wednesday’s schedule. The Under is carrying 88% of handle, reflecting expectations that Misiorowski will limit Chicago’s offense.

Marlins at Royals Odds and Splits

Market	Home (KC)	Away (MIA)	Bets %	Handle %
Moneyline	-112	-108	59% / 41%	33% / 67%
Run Line	+1.5 (-183)	-1.5 (+151)	93% / 7%	14% / 86%
Total	Over 9 (-106)	Under 9 (-113)	58% / 42%	99% / 1%

Pitching Matchup

Stat	Noah Cameron (KC)	Eury Perez (MIA)
Record	9-8	7-10
ERA	3.98	3.44
WHIP	1.219	1.133
K%	21.0%	26.8%
HR/9	0.90	0.96

One of the sharpest Run Line splits on the board: 86% of handle backs Miami -1.5 on just 7% of bets. Perez brings a half-run ERA advantage and a nearly 6-point edge in K% over Cameron. The Over holds 99% of handle in what projects as a high-scoring game in Kansas City’s heat.

Tigers at Twins Odds and Splits

Market	Home (MIN)	Away (DET)	Bets %	Handle %
Moneyline	-118	-102	52% / 48%	1% / 99%
Run Line	-1.5 (-192)	+1.5 (+157)	82% / 18%	1% / 99%
Total	Over 8.5 (-114)	Under 8.5 (-106)	50% / 50%	79% / 21%

Pitching Matchup

Stat	Dean Kremer (MIN)	Drew Anderson (DET)
Record	1-1	4-5
ERA	4.39	3.87
WHIP	1.125	1.326
K%	21.5%	26.0%
HR/9	1.01	1.36

The sharpest Moneyline split on the slate: 99% of handle backs Detroit on just 48% of bets in a near pick’em. Riley Greene was activated from the IL on September 1, giving the Tigers lineup a significant boost. Anderson owns the lower ERA of the two starters, and Detroit’s strikeout rate advantage (26.0% vs. 21.5%) gives it an edge in a matchup of two mid-tier arms.

White Sox at Astros Odds and Splits

Market	Home (HOU)	Away (CWS)	Bets %	Handle %
Moneyline	-142	+118	59% / 41%	71% / 29%
Run Line	-1.5 (+149)	+1.5 (-181)	19% / 81%	99% / 1%
Total	Over 8.5 (-115)	Under 8.5 (-105)	69% / 31%	99% / 1%

Pitching Matchup

Stat	Hayden Wesneski (HOU)	Davis Martin (CWS)
Record	4-1	9-6
ERA	3.86	4.32
WHIP	1.194	1.328
K%	21.1%	20.9%
HR/9	0.55	0.86

Houston’s Run Line draws 99% of handle on only 19% of bets, and the Over matches at 99% of handle. Wesneski’s 0.55 HR/9 is the lowest among any starter on Wednesday’s schedule. The White Sox recently acquired Tommy Pham from Philadelphia and Jake Cave from Tampa Bay, adding depth for the stretch run.

Yankees at Angels Odds and Splits

Market	Home (LAA)	Away (NYY)	Bets %	Handle %
Moneyline	+141	-171	9% / 91%	5% / 95%
Run Line	+1.5 (-131)	-1.5 (+109)	13% / 87%	0% / 100%
Total	Over 7 (+101)	Under 7 (-122)	67% / 33%	62% / 38%

Pitching Matchup

Stat	Reid Detmers (LAA)	Cam Schlittler (NYY)
Record	4-8	12-6
ERA	3.54	2.09
WHIP	1.071	0.972
K%	27.8%	30.9%
HR/9	0.99	0.77

New York’s Run Line carries 100% of handle, matching Milwaukee for the most decisive sharp lean of the day. Schlittler’s 2.09 ERA and sub-1.000 WHIP make this a lopsided pitching matchup despite Detmers’ respectable numbers. Aaron Judge remains on the 60-day IL with a rib injury, but the Yankees’ depth and pitching advantage keep them as heavy favorites.

Cardinals at Dodgers Odds and Splits

Market	Home (LAD)	Away (STL)	Bets %	Handle %
Moneyline	-258	+208	86% / 14%	94% / 6%
Run Line	-1.5 (-114)	+1.5 (-105)	77% / 23%	99% / 1%
Total	Over 8 (-108)	Under 8 (-112)	62% / 38%	99% / 1%

Pitching Matchup

Stat	Yoshinobu Yamamoto (LAD)	TBD (STL)
Record	12-8	—
ERA	2.56	—
WHIP	0.892	—
K%	25.2%	—
HR/9	0.91	—

Los Angeles is the heaviest favorite on the slate at -258, and 99% of handle backs the Run Line. Yamamoto’s 2.56 ERA and 0.892 WHIP face a Cardinals lineup that has gone 3-7 over its last 10 games. St. Louis has not announced a starter, giving the Dodgers an even larger edge. Will Smith and Dalton Rushing were both activated on September 1, restoring Los Angeles to full catching depth.