MLB Betting Splits and Odds for Friday, August 21

Looking for today’s MLB betting splits and odds? Below you’ll find the latest DraftKings Sportsbook Moneyline, Run Line and total betting percentages for every game on Friday’s slate, plus where the public and sharp money are landing before first pitch.

Today’s MLB Slate

Game	Time (ET)	Moneyline	Total
Braves @ Brewers	4:10 PM	Brewers -134 / Braves +124	O/U 6
Cardinals @ Phillies	6:40 PM	Phillies -204 / Cardinals +189	O/U 8
Blue Jays @ Yankees	7:05 PM	Yankees -231 / Blue Jays +213	O/U 7.5
Giants @ Red Sox	7:10 PM	Red Sox -170 / Giants +158	O/U 7.5
Nationals @ Marlins	7:10 PM	Marlins -146 / Nationals +136	O/U 8
Rays @ Orioles	7:15 PM	Orioles -124 / Rays +116	O/U 7.5
Mets @ White Sox	7:40 PM	White Sox -141 / Mets +131	O/U 8
Athletics @ Astros	8:10 PM	Astros -181 / A’s +168	O/U 8
Tigers @ Royals	8:10 PM	Tigers -113 / Royals +105	O/U 8
Angels @ Rangers	8:15 PM	Rangers -140 / Angels +131	O/U 7.5
Guardians @ Rockies	8:40 PM	Guardians -148 / Rockies +138	O/U 10.5
Reds @ Diamondbacks	9:40 PM	D-backs -141 / Reds +131	O/U 8.5
Twins @ Padres	9:40 PM	Padres -133 / Twins +124	O/U 8
Pirates @ Dodgers	10:10 PM	Dodgers -245 / Pirates +198	O/U 8
Cubs @ Mariners	10:10 PM	Mariners -112 / Cubs -108	O/U 8

Best Bets for Friday’s MLB Slate

Tigers Run Line -1.5 (+139): The widest sharp signal on Friday’s board: 97% of the handle backs Detroit to cover on just 50% of bets, driven by Troy Melton’s elite 1.49 ERA and 0.961 WHIP.
D-backs Run Line -1.5 (+143): Only 43% of bets but 97% of the handle, a massive 54-point gap signaling sharp conviction in Arizona behind Eduardo Rodriguez at home.
Over 8 Mets/White Sox (-105): Sharp money is hammering the Over with 94% of the handle on just 50% of bets, the largest total-market handle gap on the east-coast slate.
Cam Schlittler OVER 6.5 Strikeouts (-126): Has cleared this number in 7 of his last 10 starts, averaging 8.0 K per outing over that stretch.
Angels Moneyline (+131): Despite 66% of bets on Texas, 65% of the handle favors Los Angeles behind Reid Detmers’ quietly strong 1.056 WHIP and 28.8% K rate.

Brewers at Braves Odds and Splits

Market	Home (Brewers)	Away (Braves)	Bets %	Handle %
Moneyline	-134	+124	72% / 28%	85% / 15%
Run Line	-1.5 (+170)	+1.5 (-207)	56% / 44%	44% / 56%
Total	Over 6 (-111)	Under 6 (-109)	73% / 28%	73% / 27%

Pitching Matchup

Stat	Jacob Misiorowski (MIL)	Chris Sale (ATL)
Record	12-5	12-8
ERA	1.75	2.16
WHIP	0.748	1.016
K%	39.8%	30.9%
HR/9	0.84	0.56

An elite pitching matchup justifies the low 6-run total. Public and sharp money are aligned on Milwaukee, with both bets (72%) and handle (85%) favoring the Brewers behind Misiorowski’s dominant 0.748 WHIP.

Phillies at Cardinals Odds and Splits

Market	Home (Phillies)	Away (Cardinals)	Bets %	Handle %
Moneyline	-204	+189	79% / 21%	90% / 10%
Run Line	-1.5 (+102)	+1.5 (-123)	63% / 37%	36% / 64%
Total	Over 8 (-110)	Under 8 (-110)	50% / 50%	47% / 53%

Pitching Matchup

Stat	Jesus Luzardo (PHI)	Hunter Dobbins (STL)
Record	11-5	3-3
ERA	3.23	3.42
WHIP	1.151	1.300
K%	29.8%	23.1%
HR/9	0.72	1.26

Sharp money is fading the Phillies Run Line despite heavy public support, with 64% of the handle taking St. Louis +1.5 against just 37% of bets. Dobbins’ 1.26 HR/9 is a concern at hitter-friendly Citizens Bank Park.

Yankees at Blue Jays Odds and Splits

Market	Home (Yankees)	Away (Blue Jays)	Bets %	Handle %
Moneyline	-231	+213	83% / 17%	49% / 51%
Run Line	-1.5 (-108)	+1.5 (-112)	78% / 22%	76% / 24%
Total	Over 7.5 (-110)	Under 7.5 (-110)	57% / 43%	50% / 50%

Pitching Matchup

Stat	Cam Schlittler (NYY)	Mason Fluharty (TOR)
Record	10-6	5-1
ERA	2.19	3.71
WHIP	0.941	1.235
K%	31.4%	26.3%
HR/9	0.83	1.06

The sharpest Moneyline split on the board: 83% of bets are on New York, but 51% of the handle backs Toronto at +213. Sharp bettors are fading the public price on the Yankees despite Schlittler’s dominance — Fluharty’s 5-1 record and solid K rate may be the value angle.

Red Sox at Giants Odds and Splits

Market	Home (Red Sox)	Away (Giants)	Bets %	Handle %
Moneyline	-170	+158	91% / 9%	96% / 4%
Run Line	-1.5 (+126)	+1.5 (-152)	86% / 14%	99% / 1%
Total	Over 7.5 (-102)	Under 7.5 (-119)	48% / 52%	57% / 43%

Pitching Matchup

Stat	Sonny Gray (BOS)	Logan Webb (SF)
Record	15-3	8-7
ERA	2.65	3.50
WHIP	1.146	1.065
K%	21.8%	19.6%
HR/9	0.88	0.58

Near-unanimous consensus: 99% of the handle backs Boston’s Run Line. Gray owns a 15-3 record and the public is confident at home. No contrarian signal present.

Marlins at Nationals Odds and Splits

Market	Home (Marlins)	Away (Nationals)	Bets %	Handle %
Moneyline	-146	+136	59% / 41%	69% / 31%
Run Line	-1.5 (+143)	+1.5 (-174)	37% / 63%	79% / 21%
Total	Over 8 (-102)	Under 8 (-118)	78% / 22%	95% / 5%

Pitching Matchup

Stat	Ryan Gusto (MIA)	Brad Lord (WSH)
Record	0-3	5-2
ERA	4.70	4.04
WHIP	1.323	1.251
K%	20.7%	21.2%
HR/9	1.34	1.01

Sharp money strongly backs Miami’s Run Line (79% handle, 37% bets) and the Over (95% handle, 78% bets). Two elevated HR/9 rates and limited strikeout potential suggest offense should flow.

Orioles at Rays Odds and Splits

Market	Home (Orioles)	Away (Rays)	Bets %	Handle %
Moneyline	-124	+116	45% / 55%	73% / 27%
Run Line	-1.5 (+159)	+1.5 (-194)	25% / 75%	20% / 80%
Total	Over 7.5 (-119)	Under 7.5 (-101)	61% / 39%	47% / 53%

Pitching Matchup

Stat	Trevor Rogers (BAL)	Freddy Peralta (TB)
Record	8-8	0-1
ERA	4.15	7.54
WHIP	1.249	1.465
K%	20.4%	16.4%
HR/9	0.93	1.88

Sharp money favors Baltimore (73% handle on 45% of bets) against Peralta’s 7.54 ERA and 1.88 HR/9. The Under is also drawing smart-money attention, suggesting bettors expect Baltimore’s offense to control the pace.

White Sox at Mets Odds and Splits

Market	Home (White Sox)	Away (Mets)	Bets %	Handle %
Moneyline	-141	+131	76% / 24%	64% / 36%
Run Line	-1.5 (+144)	+1.5 (-175)	50% / 50%	67% / 33%
Total	Over 8 (-105)	Under 8 (-115)	50% / 50%	94% / 6%

Pitching Matchup

Stat	Sean Burke (CWS)	Sean Manaea (NYM)
Record	7-6	4-5
ERA	3.15	4.22
WHIP	1.107	1.315
K%	27.0%	23.5%
HR/9	1.03	1.30

Friday’s most dramatic total split: 94% of the handle is on the Over with just 50% of the bets, a 44-point gap that screams sharp conviction. Manaea’s 1.30 HR/9 and the White Sox’s power-friendly environment support the thesis.

Astros at Athletics Odds and Splits

Market	Home (Astros)	Away (Athletics)	Bets %	Handle %
Moneyline	-181	+168	80% / 20%	94% / 6%
Run Line	-1.5 (+113)	+1.5 (-136)	52% / 48%	26% / 74%
Total	Over 8 (-111)	Under 8 (-109)	72% / 28%	87% / 13%

Pitching Matchup

Stat	Hayden Wesneski (HOU)	J.T. Ginn (ATH)
Record	2-1	8-7
ERA	5.16	3.53
WHIP	1.324	1.217
K%	18.9%	21.4%
HR/9	0.79	0.99

Despite Houston’s clear Moneyline consensus, 74% of the handle backs Athletics +1.5 on just 48% of bets. Sharp money is hedging against the Run Line spread, trusting Ginn to keep this competitive under the roof.

Royals at Tigers Odds and Splits

Market	Home (Royals)	Away (Tigers)	Bets %	Handle %
Moneyline	+105	-113	37% / 63%	16% / 84%
Run Line	+1.5 (-168)	-1.5 (+139)	50% / 50%	3% / 97%
Total	Over 8 (-118)	Under 8 (-102)	45% / 55%	14% / 86%

Pitching Matchup

Stat	Noah Cameron (KC)	Troy Melton (DET)
Record	7-8	7-1
ERA	4.16	1.49
WHIP	1.222	0.961
K%	21.7%	22.2%
HR/9	0.91	0.85

The sharpest conviction play on the entire slate. A staggering 97% of the handle backs Detroit -1.5 on just 50% of bets, and 86% of the handle is on the Under. Melton’s 1.49 ERA and sub-1.0 WHIP justify the sharp stampede toward a low-scoring Tigers win.

Rangers at Angels Odds and Splits

Market	Home (Rangers)	Away (Angels)	Bets %	Handle %
Moneyline	-140	+131	66% / 34%	35% / 65%
Run Line	-1.5 (+153)	+1.5 (-186)	45% / 55%	66% / 34%
Total	Over 7.5 (-102)	Under 7.5 (-118)	45% / 55%	34% / 66%

Pitching Matchup

Stat	MacKenzie Gore (TEX)	Reid Detmers (LAA)
Record	7-9	4-8
ERA	4.45	3.78
WHIP	1.260	1.056
K%	25.8%	28.8%
HR/9	1.16	1.07

A strong contrarian Moneyline lean: 65% of the handle backs the Angels despite only 34% of bets. Detmers’ superior WHIP and K rate under the Globe Life Field roof give Los Angeles a pitching edge the public is overlooking.

Rockies at Guardians Odds and Splits

Market	Home (Rockies)	Away (Guardians)	Bets %	Handle %
Moneyline	+138	-148	17% / 83%	14% / 86%
Run Line	+1.5 (-118)	-1.5 (-102)	54% / 46%	15% / 85%
Total	Over 10.5 (-112)	Under 10.5 (-108)	65% / 35%	100% / 0%

Pitching Matchup

Stat	Tanner Gordon (COL)	Joey Cantillo (CLE)
Record	0-3	9-7
ERA	5.55	3.80
WHIP	1.444	1.440
K%	19.9%	25.6%
HR/9	1.89	1.07

Every dollar is on the Over: 100% of the handle at 10.5 in Coors Field. Gordon’s 1.89 HR/9 at altitude, combined with Cleveland’s lineup, makes this the most one-sided total on Friday’s slate. Sharp money also backs the Guardians Run Line at 85% handle.

Diamondbacks at Reds Odds and Splits

Market	Home (D-backs)	Away (Reds)	Bets %	Handle %
Moneyline	-141	+131	79% / 21%	88% / 12%
Run Line	-1.5 (+143)	+1.5 (-174)	43% / 57%	97% / 3%
Total	Over 8.5 (-102)	Under 8.5 (-118)	72% / 28%	43% / 57%

Pitching Matchup

Stat	Eduardo Rodriguez (AZ)	Nick Lodolo (CIN)
Record	12-4	3-2
ERA	2.71	4.52
WHIP	1.212	1.423
K%	17.3%	18.0%
HR/9	0.84	1.51

A massive 54-point Run Line gap (97% handle, 43% bets) makes Arizona the second-sharpest cover play on the slate. Rodriguez’s 2.71 ERA at home against Lodolo’s 1.51 HR/9 gives the D-backs a clear edge under the roof at Chase Field.

Padres at Twins Odds and Splits

Market	Home (Padres)	Away (Twins)	Bets %	Handle %
Moneyline	-133	+124	88% / 12%	91% / 9%
Run Line	-1.5 (+153)	+1.5 (-187)	43% / 57%	95% / 5%
Total	Over 8 (-115)	Under 8 (-105)	88% / 13%	100% / 0%

Pitching Matchup

Stat	Randy Vasquez (SD)	Connor Prielipp (MIN)
Record	8-6	3-6
ERA	4.30	5.34
WHIP	1.378	1.380
K%	15.0%	24.6%
HR/9	1.22	1.23

Sharp money overwhelmingly backs San Diego to cover (95% handle on 43% of bets) and the Over (100% handle). Two pitchers with 1.2+ HR/9 and elevated WHIPs at Petco Park explain the offensive lean, though the marine layer could moderate scoring late.

Dodgers at Pirates Odds and Splits

Market	Home (Dodgers)	Away (Pirates)	Bets %	Handle %
Moneyline	-245	+198	94% / 6%	93% / 7%
Run Line	-1.5 (-109)	+1.5 (-110)	69% / 31%	86% / 14%
Total	Over 8 (-114)	Under 8 (-105)	75% / 25%	100% / 0%

Pitching Matchup

Stat	Yoshinobu Yamamoto (LAD)	Bubba Chandler (PIT)
Record	12-7	6-8
ERA	2.60	4.23
WHIP	0.895	1.368
K%	24.5%	20.5%
HR/9	0.93	0.74

The biggest favorite on the board. Yamamoto’s 0.895 WHIP makes the Dodgers a near-unanimous pick, and 100% of the handle is on the Over. Public and sharp money agree on a comfortable Los Angeles win with offense.

Mariners at Cubs Odds and Splits

Market	Home (Mariners)	Away (Cubs)	Bets %	Handle %
Moneyline	-112	-108	37% / 63%	23% / 77%
Run Line	+1.5 (-193)	-1.5 (+158)	50% / 50%	1% / 99%
Total	Over 8 (-105)	Under 8 (-115)	53% / 47%	93% / 7%

Pitching Matchup

Stat	Emerson Hancock (SEA)	Matthew Boyd (CHC)
Record	7-7	8-2
ERA	3.31	4.02
WHIP	1.109	1.235
K%	23.1%	19.2%
HR/9	1.13	1.38

Despite a near-pick’em line, sharp money is aggressively backing Chicago: 99% of the Run Line handle and 93% of the total handle favor the Cubs side and scoring. Boyd’s 1.38 HR/9 under the T-Mobile Park roof could be the vulnerability sharps are targeting.