DKNetwork Logo DKNetwork Logo
DraftKings MLB Pick6 Fantasy Baseball Picks: Top Plays for Friday 8/21/26

DraftKings MLB Pick6 Fantasy Baseball Picks: Top Plays for Friday 8/21/26

Published:

By: Blake Krass

The MLB season is into the second half, but there is still a lot of baseball left to play. One of the more unique features on DraftKings this year is Pick6 Fantasy Baseball!

Here are my top Pick6 plays for today’s MLB slate.

DraftKings MLB Pick6 Plays

Cam Schlittler More Than 5.5 Strikeouts Thrown (Promo Pick)

Cam Schlittler is having an excellent season for the Yankees. He is the current favorite to win the AL Cy Young, ranking inside the top four in the MLB in ERA, strikeouts and WHIP. Tonight, he has a familiar matchup against the Blue Jays. This will be Schlittler’s second consecutive start against the Blue Jays, having just faced them six days ago. In that matchup, he registered seven strikeouts. Thanks to this exciting DraftKings Pick6 promo, users only need Schlittler to throw more than 5.5 strikeouts, rather than 6.5. Schlittler has thrown at least six strikeouts in eight straight starts coming into this one. He should replicate his performance against the Blue Jays from last week and clear this number for the ninth straight time.

Randal Grichuk More Than 1.5 Total Bases

Randal Grichuk missed some time to start the season. He played just a handful of games for the Yankees before getting moved to the White Sox. He was poor while in New York, but has thrived in Chicago. He has a .911 OPS since joining the White Sox, the best mark on the team. Grichuk is also red hot at the moment. Over the last 15 days, Grichuk is hitting .379 with a 1.103 OPS. He has been particularly strong against lefties this season, with a .985 OPS against southpaws. He should step up tonight against the left-handed Sean Manaea. Manaea has a 4.22 ERA and a 1.32 WHIP this season, and right-handed hitters have an .829 OPS against him. Grichuk is also 6-for-19 with two home runs in his career against Manaea, coming out to a 1.170 OPS.

Yandy Diaz More Than 1.5 Hits + Runs + RBIs

Yandy Diaz is having an excellent season in Tampa. He is batting .308, the fifth-best mark in baseball in 2026. After a dip in form in July, he has gotten red hot throughout the month of August. Diaz is batting .368 with a 1.000 OPS over the past 15 days. He should keep that momentum going tonight against Trevor Rogers. Rogers has a 4.15 ERA and a 1.25 WHIP this season. He has been excellent in lefty-on-lefty matchups, but right-handed hitters have a .773 OPS against him this season. Diaz is also 7-for-13 with three extra-base hits in his career against Rogers. He should keep that success going and clear this number tonight.


What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.

How to Play

Create a Pick Set

Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you cannot pick the same player twice, and you must pick players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.


Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!


Gambling Problem? Call 1-800-GAMBLER. Must be at least 18 years or older. Higher age limits may apply in some states. Eligibility restrictions apply. Valid only in states where DraftKings Pick6 operates. Void where prohibited. For entertainment purposes only. Winning a contest on DraftKings depends on knowledge and exercise of skill. See terms at pick6.draftkings.com.


Blake Krass

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.