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DraftKings MLB Pick6 Fantasy Baseball Picks: Top Plays for Wednesday 8/5/26

DraftKings MLB Pick6 Fantasy Baseball Picks: Top Plays for Wednesday 8/5/26

Published:

By: Blake Krass

The MLB season is rolling along. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings is Pick6 Fantasy Baseball!

Here are my top Pick6 plays for today’s MLB slate.


DraftKings MLB Pick6 Plays

Riley Greene More Than 1.5 Total Bases

It has been an excellent season in Detroit for Riley Greene. He is batting .278 with an .830 OPS in 2026. That is despite some relative struggles against left-handed pitching. Against righties, Greene has been one of the best hitters in baseball. He is batting .305 with a .904 OPS against right-handers this season. Greene should be in for a good game against the right-handed Bryan Woo. Woo has a 4.56 ERA this season and has had real problems against lefties. Left-handed hitters have a .713 OPS against Woo this season, compared to righties, who have a .593 OPS. Greene had three hits in the series opener against the Mariners on Tuesday night and should keep it rolling on Wednesday.


Trea Turner More Than 1.5 Hits + Runs + RBIs

Trea Turner has dramatically turned his season around after a terrible start. Turner was having the worst season of his career before he got red hot through July and into the start of August. Over the last 30 days, Turner is batting .316 with a .942 OPS. He should be in for a big game against Jake Irvin tonight. Irvin has a 5.56 ERA and a 1.32 WHIP this season, and has been crushed by righties. Irvin is allowing right-handers to bat .275 with an .800 OPS against him this season. Turner has also been much better against right-handed pitching, so everything sets up for him to have a big night against Irvin.


Otto Lopez More Than 1.5 Total Bases

Otto Lopez was named to his first MLB All-Star Game this season. In his third season in Miami, Lopez has taken a giant leap forward as a hitter. He ranks third in the MLB with a .326 batting average this season. He has been excellent on every level, at home or on the road, against right-handers or left-handers, during the day or at night. Lopez has also been great against tonight’s starter, Bryce Elder. In eight career at-bats against Elder, Lopez has four hits. Right-handed hitters are batting .292 with an .801 OPS against Elder this season overall. Lopez should keep his bat red hot against Elder and get over 1.5 total bases in this game.


What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether or not you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.

How to Play

Create a Pick Set

Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.


Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!


Gambling Problem? Call 1-800-GAMBLER. Must be at least 18 years or older. Higher age limits may apply in some states. Eligibility restrictions apply. Valid only in states where DraftKings Pick6 operates. Void where prohibited. For entertainment purposes only. Winning a contest on DraftKings depends on knowledge and exercise of skill. See terms at pick6.draftkings.com.


Blake Krass has contributed to DraftKings since 2024, and is a content creator with a specialty in sports betting. Blake primarily focuses on college football and NFL coverage but will also be covering college basketball, the NBA, MLB and more. Prior to arriving at DK, Blake was a sports betting writer for The Action Network.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.