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Best James Harden prop bet for Cavaliers vs. Knicks Game 2 on Thursday 5/21/26

Best James Harden prop bet for Cavaliers vs. Knicks Game 2 on Thursday 5/21/26

Published:

By: Cooper Albers

The Cleveland Cavaliers look to bounce back from an epic late-game collapse on Thursday, taking on the New York Knicks in Game 2 of the Eastern Conference Finals at Madison Square Garden.  

The Cavaliers held a 22-point lead with less than eight minutes to go in Game 1 — until Jalen Brunson turned James Harden into his own personal punching bag. The squad will need more from its prized trade-deadline acquisition, hoping to even up the series before it shifts to Cleveland. 

Tipoff is set for 8:10 p.m. ET. New York is a 5.5-point home favorite with -205 moneyline odds, while Cleveland is a +170 underdog. 

Ahead of Game 2, let’s dive into the top James Harden prop bet on DraftKings Sportsbook.


Best James Harden Prop Bet for Cavaliers vs. Knicks Game 2

James Harden Over 24.5 Points + Assists (-122)

James Harden’s already questionable playoff reputation took another hit in Tuesday’s Game 1 loss to the Knicks. He was stranded on an island down the stretch against Jalen Brunson, who fueled a historic fourth-quarter comeback en route to a 115–104 overtime win. 

Making matters worse, the former MVP — acquired at the trade deadline to bolster Cleveland’s championship aspirations — finished with only 15 points (5–16 FG, 1–8 3PT), four rebounds, three assists, and six turnovers in 42 minutes.

While he’s coming off back-to-back lackluster outings — he was limited to just nine points in Game 7 against the Pistons — Harden has still had a fairly impressive postseason run. The perennial All-Star is averaging 25.7 combined points and assists (P+A) in the playoffs, clearing 24.5 P+A in 10 of 14 matchups with Toronto and Detroit.

If his shooting woes persist, the two-time assist champ should tap back into his exceptional playmaking, fortifying a strong statistical floor. Count on Harden to bounce back Thursday night, recording more than 24.5 P+A in Game 2 at The Garden.

Cooper is a Brooklyn-based writer and editor who joined DraftKings in September 2025. A recent graduate of Jay-Z’s Roc Nation School of Sports at Long Island University, he served as the chief sports editor of the campus newspaper and the lead sideline reporter for the men’s basketball team. His previous stops include amNewYork and the New York Post.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.