Looking for today’s MLB probable pitchers? Here’s the full list of starting pitcher matchups for May 21, 2026, including game times and embedded widgets with odds, strikeout props, and team trends. You can also find the latest odds and player props for today’s games on DraftKings Sportsbook.
Today’s slate features a lighter schedule, highlighted by Spencer Strider facing Sandy Alcantara in Miami, Casey Mize continuing his breakout season for Detroit, and Jose Soriano looking to rebound after a rough recent stretch for the Angels.
Cleveland Guardians vs. Detroit Tigers Probable Pitchers
- Cleveland Guardians: Joey Cantillo
- Detroit Tigers: Casey Mize
- Time: 1:10 PM ET
Cantillo has been very strong against left-handed bats, with a .263 wOBA and a 3.19 FIP. Mize has been fantastic through seven starts, posting a 2.43 ERA with an xERA of 2.98 and a 9.4 K/9.
Pittsburgh Pirates vs. St. Louis Cardinals Probable Pitchers
- Pittsburgh Pirates: Braxton Ashcraft
- St. Louis Cardinals: Dustin May
- Time: 1:15 PM ET
Ashcraft hasn’t allowed more than two earned runs in seven of his nine starts this season. Against lefties, May has a .397 wOBA with a 4.96 FIP and three of the four home runs he’s allowed.
New York Mets vs. Washington Nationals Probable Pitchers
- New York Mets: TBD
- Washington Nationals: Cade Cavalli
- Time: 4:05 PM ET
In his prior start against the Mets, Cavalli allowed two runs on eight hits and 10 strikeouts through six innings.
Atlanta Braves vs. Miami Marlins Probable Pitchers
- Atlanta Braves: Spencer Strider
- Miami Marlins: Sandy Alcantara
- Time: 6:40 PM ET
Strider has been excellent since his return, posting a 2.45 ERA with a 2.89 xERA and a K/9 of 11 through 14.2 innings. Alcantara has thrown at least six innings in eight of his 10 starts.
Toronto Blue Jays vs. New York Yankees Probable Pitchers
- Toronto Blue Jays: TBD
- New York Yankees: Carlos Rodon
- Time: 7:05 PM ET
Through two starts, Rodon has allowed six runs on five hits with 10 strikeouts and eight walks through 8.0 innings.
Athletics vs. Los Angeles Angels Probable Pitchers
- Athletics: Luis Severino
- Los Angeles Angels: Jose Soriano
- Time: 9:38 PM ET
While Severino still has an unsightly 5.1 BB/9, but he’s limited the walks as of late. He’s only issued eight through 16.1 innings in the month of May. After allowing just one single run in his first six starts, Soriano has been tagged for 15 runs in his last four.
Colorado Rockies vs. Arizona Diamondbacks Probable Pitchers
- Colorado Rockies: Tomoyuki Sugano
- Arizona Diamondbacks: Eduardo Rodriguez
- Time: 9:40 PM ET
Sugano has a 4.02 ERA with an xERA of 7.25 and a 5.50 FIP. Rodriguez currently has the lowest K/9 of his career at 6.5 through 53.1 innings.
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