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Opening odds and spread for 49ers vs Rams in NFL Week 1

Opening odds and spread for 49ers vs Rams in NFL Week 1

NFL Sports Betting Picks NFL Betting DraftKings Sportsbook Insights

Published:

By: Ciaran Doyle

The opening odds for the San Francisco 49ers vs. Los Angeles Rams Week 1 matchup on Thursday Night Football are now available on DraftKings Sportsbook.

49ers vs. Rams Opening Odds

The Rams open as 2.5-point favorites for this game. They are -155 favorites on the moneyline, while the 49ers are +130 underdogs. The O/U is listed at 48.5 points.

These teams split the regular season series last year, with the road team winning on both occasions. The 49ers won in L.A. in Week 5, 26-23 in OT. In Week 10, the Rams went to San Francisco and got the 42-26 victory.

We’ve got a blockbuster NFC West matchup set for the first Thursday Night Football matchup of the season. Let’s see who comes out on top.

Ciaran Doyle
Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
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