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MLB Best Bets: Top Home Run Props for Tuesday 5/5/26

MLB Best Bets: Top Home Run Props for Tuesday 5/5/26

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By: Garion Thorne

Home runs. Long balls. Bleacher reachers. Whatever you want to call them, people love watching and betting on home run props during baseball games. So much so, we’ve got a whole article dedicated to just that.

Here are my top three home run prop picks on DraftKings Sportsbook for tonight’s full 15-game slate: Bryan Reynolds and Bryce Harper.

Let’s break them down.

Top MLB Home Run Props

Bryan Reynolds 1+ Home Run (+720)

Eduardo Rodriguez had quite the little run there, didn’t he? The veteran southpaw started Venezuela’s gold medal win against the USA at the WBC, then he carried that success into the regular season with the Diamondbacks, not allowing an earned run in either of his first two outings of 2026. However, it is my regret to inform you that the carriage has turned back into a pumpkin. Rodriguez has been in a steady decline for the past couple years, and his last four starts seem far more in line with that larger trend. It’s a span where the 33-year-old has pitched to a 6.19 FIP with nearly as many walks (13) as strikeouts (14). It’s also a span where Rodriguez is surrendering 1.74 opponent home runs per nine.

Now, the Pirates’ lineup is pretty full of left-handed bats, so it makes sense that the team has thrived more in matchups with RHPs. That said, Bryan Reynolds is a switch-hitter that’s had a lot of impact as an RHB since the beginning of 2025. Heck, even since the start of this season, Reynolds is slashing .282/.404/.487 with a .205 ISO and a 152 wRC+ within the split. I’d give him a serious look in this market this evening. Remember, he’ll also likely get a couple plate appearances against a Diamondbacks bullpen that’s top 10 in baseball in long balls conceded (17).

Bryce Harper 1+ Home Run (+356)

If I’m being completely honest, this pick is less a criticism of Luis Severino, than it is an endorsement of the weather tonight in Philadelphia. It’s supposed to be warm and the wind is supposed to be blowing straight out to center with 15-20 mph gusts. That, my friends, is called perfect home run conditions.

Allow me to give Bryce Harper his flowers, too. The former MVP hasn’t had a truly elite campaign since all the way back in 2021, yet Harper’s been pretty damn good to begin 2026, with seven home runs and a .248 ISO in his opening 149 plate appearances. The 33-year-old has also mustered 93rd percentile marks in both expected wOBA (.396) and expected slugging rate (.553). The cherry on top of the sundae? In eight career at-bats against Severino, who used to call the NL East home, Harper has three hits. All three left the park. I don’t like leaning on BvP too much, but this time, it seems relevant to the conversation.

All views expressed are my own. I am an employee of DraftKings and am ineligible to play in public DFS or DKSB contests.