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Atlético Madrid vs. Arsenal prediction, pick for Wednesday 4/29/26

Atlético Madrid vs. Arsenal prediction, pick for Wednesday 4/29/26

Published:

By: Ciaran Doyle

The UEFA Champions League semi-finals continue on Wednesday as Arsenal will travel to take on Atlético Madrid.

Arsenal are slight +155 favorites on the moneyline, while a draw is available at +225. Fancy an Atlético Madrid upset? They are +185 on the moneyline on DraftKings Sportsbook.

In terms of odds to advance to the final, Arsenal are the favorite at -215, while Atlético Madrid are listed at +165.

Atlético Madrid vs. Arsenal Prediction, Pick

The first leg of this Champions League semi-final has all the makings of a defensive showdown. Both Mikel Arteta and Diego Simeone are known for their pragmatic approaches to these kinds of matches. I’m expecting this game to play out just as expected, but I’ll give the edge to the Gunners based on their Champions League record this season.

In 12 games in this season’s competition, Arsenal have won 10 and drawn twice. They are still awaiting their first loss. For Atlético Madrid, they have struggled quite a bit more but all that matters is that you survive and advance. In their 14 matches, they have won seven, drawing twice and losing five times.

These teams actually met up earlier this season back in October in the League Phase, with Arsenal winning 4-0 at home. The Gunners were in much better form at that point of the season, but it was still a dominant performance against this same opposition. Arsenal finished with more shots, more shots on target, more possession and more importantly, a 4-0 win.

Neither of these teams come into this massive match in scorching form. Atlético have lost two of their last three games since their last UCL game, while Arsenal have lost one and won one since their second-leg match against Sporting Lisbon. Although they’re on the road and struggling to score goals at the moment, it’s hard for me to pick against this stout Arsenal defense. I’m not sure if they will get the win, but I also do not see them losing this first leg.

Best Bet: Arsenal Tie No Bet (-125)

Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.