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MLB DFS Picks: Starting Pitcher Rankings for Wednesday 4/22/26

MLB DFS Picks: Starting Pitcher Rankings for Wednesday 4/22/26

Published:

By: Sam Connon

The 2026 MLB regular season is in full-swing. There’s another jam-packed slate on the books Wednesday, so there is no better time to dive right into the action. Pitchers are already ranked by price, with the ones who are projected to perform better eating up more of your budget, but I am here to add my two cents. I have my own DFS rankings for the top 10 starting pitchers in the nine-game Wednesday night contest that locks at 6:40 p.m. ET.

Set your DraftKings fantasy baseball lineups here: MLB $300K Mega 8’s ($100K to 1st)

Note: LAD RHP Shohei Ohtani is pitching Wednesday night and will not accrue hitting fantasy points.

1. RHP Shohei Ohtani, LAD (@ SFG)

Salary: $10,100

2025 Stats: 14 G, 14 GS, 47.0 IP, 1-1, 2.87 ERA, 1.04 WHIP, 62 K, 9 BB, 1.9 WAR
2026 Stats: 3 G, 3 GS, 18.0 IP, 2-0, 0.50 ERA, 0.72 WHIP, 18 K, 6 BB, 0.7 WAR
2026 FanGraphs ROS Projections: 21 G, 21 GS, 109.0 IP, 8-6, 3.39 ERA, 1.16 WHIP, 127 K, 37 BB, 2.6 WAR (Steamer)

2. LHP Max Fried, NYY (@ BOS)

Salary: $9,700

2025 Stats: 32 G, 32 GS, 195.1 IP, 19-5, 2.86 ERA, 1.10 WHIP, 189 K, 51 BB, 4.8 WAR
2026 Stats: 5 G, 5 GS, 33.1 IP, 2-1, 2.97 ERA, 0.81 WHIP, 23 K, 8 BB, 0.8 WAR
2026 FanGraphs ROS Projections: 26 G, 26 GS, 164.0 IP, 11-8, 3.38 ERA, 1.24 WHIP, 153 K, 50 BB, 3.1 WAR (Steamer)

3. RHP Clay Holmes, NYM (vs. MIN)

Salary: $8,900

2025 Stats: 33 G, 31 GS, 165.2 IP, 3.53 ERA, 12-8, 1.30 WHIP, 129 K, 66 BB, 1.9 WAR
2026 Stats: 4 G, 4 GS, 23.0 IP, 2-2, 1.96 ERA, 1.09 WHIP, 16 K, 9 BB, 0.2 WAR
2026 FanGraphs ROS Projections: 24 G, 24 GS, 133.0 IP, 8-8, 3.92 ERA, 1.41 WHIP, 111 K, 58 BB, 1.5 WAR (Steamer)

4. LHP Eduardo Rodríguez, ARI (@ CHC)

Salary: $8,400

2025 Stats: 29 G, 29 GS, 154.1 IP, 9-9, 5.02 ERA, 1.54 WHIP, 143 K, 60 BB, 0.2 WAR
2026 Stats: 4 G, 4 GS, 23.0 IP, 1-0, 1.96 ERA, 1.22 WHIP, 14 K, 9 BB, 0.2 WAR
2026 FanGraphs ROS Projections: 29 G, 22 GS, 130.0 IP, 8-8, 4.33 ERA, 1.39 WHIP, 113 K, 49 BB, 1.4 WAR (Steamer)

5. RHP Braxton Ashcraft, PIT (@ TEX)

Salary: $8,200

2025 Stats: 26 G, 8 GS, 69.2 IP, 4-4, 2.71 ERA, 1.25 WHIP, 71 K, 24 BB, 1.6 WAR
2026 Stats: 4 G, 4 GS, 22.2 IP, 1-1, 2.38 ERA, 1.06 WHIP, 27 K, 7 BB, 1.0 WAR
2026 FanGraphs Projections: 33 G, 19 GS, 120.0 IP, 7-7, 3.89 ERA, 1.31 WHIP, 109 K, 42 BB, 1.8 WAR (Steamer)

6. RHP Casey Mize, DET (vs. MIL)

Salary: $7,900

2025 Stats: 28 G, 28 GS, 149.0 IP, 14-6, 3.87 ERA, 1.27 WHIP, 139 K, 36 BB, 2.4 WAR
2026 Stats: 4 G, 4 GS, 22.2 IP, 1-1, 2.78 ERA, 1.19 WHIP, 25 K, 7 BB, 0.6 WAR
2026 FanGraphs ROS Projections: 23 G, 23 GS, 129.0 IP, 8-8, 3.97 ERA, 1.26 WHIP, 118 K, 38 BB, 1.9 WAR (Steamer)

7. LHP Ranger Suárez, BOS (vs. NYY)

Salary: $8,000

2025 Stats: 26 G, 26 GS, 157.1 IP, 3.20 ERA, 12-8, 1.22 WHIP, 151 K, 38 BB, 4.0 WAR
2026 Stats: 4 G, 4 GS, 22.1 IP, 1-1, 3.22 ERA, 1.07 WHIP, 15 K, 6 BB, 0.4 WAR
2026 FanGraphs ROS Projections: 25 G, 25 GS, 149.0 IP, 9-8, 3.75 ERA, 1.30 WHIP, 131 K, 46 BB, 2.8 WAR (Steamer)

8. RHP Chad Patrick, MIL (@ DET)

Salary: $7,600

2025 Stats: 27 G, 23 GS, 119.2 IP, 3-8, 3.53 ERA, 1.28 WHIP, 127 K, 40 BB, 2.6 WAR
2026 Stats: 4 G, 3 GS, 19.0 IP, 1-0, 0.95 ERA, 1.16 WHIP, 9 K, 7 BB, 0.2 WAR
2026 FanGraphs Projections: 22 G, 22 GS, 127.0 IP, 7-9, 4.53 ERA, 1.33 WHIP, 111 K, 46 BB, 1.0 WAR (Steamer)

9. RHP Jack Leiter, TEX (vs. PIT)

Salary: $8,800

2025 Stats: 29 G, 29 GS, 151.2 IP, 11-8, 3.86 ERA, 1.28 WHIP, 148 K, 67 BB, 2.3 WAR
2026 Stats: 4 G, 4 GS, 18.1 IP, 1-1, 4.87 ERA, 1.48 WHIP, 24 K, 9 BB, 0.2 WAR
2026 FanGraphs ROS Projections: 24 G, 24 GS, 128.0 IP, 7-8, 4.38 ERA, 1.38 WHIP, 126 K, 58 BB, 1.5 WAR (Steamer)

10. LHP Matthew Boyd, CHC (vs. PHI)

Salary: $7,700

2025 Stats: 31 G, 31 GS, 179.2 IP, 14-8, 3.21 ERA, 1.09 WHIP, 154 K, 42 BB, 3.4 WAR
2026 Stats: 2 G, 2 GS, 9.1 IP, 1-1, 6.75 ERA, 1.18 WHIP, 17 K, 3 BB, 0.3 WAR
2026 FanGraphs ROS Projections: 24 G, 24 GS, 132.0 IP, 9-8, 3.79 ERA, 1.24 WHIP, 126 K, 43 BB, 1.9 WAR (Steamer)

Sam joined DraftKings in 2025 following five years with Sports Illustrated’s “On SI” network. He has covered the UCLA Bruins, New England Patriots, Tampa Bay Rays, MLB, MiLB and NBA, on top of earning awards from the Society of Professional Journalists and College Media Association during his time as a student at UCLA.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.