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MLB Best Bets Today: Top Expert Picks and Predictions for Wednesday 4/22/26

MLB Best Bets Today: Top Expert Picks and Predictions for Wednesday 4/22/26

Sports Betting Picks MLB DraftKings Sportsbook Insights Rail

Published:

By: DK.Network.Editors

Looking for the best MLB picks today? Get top bets, player props and expert predictions for Wednesday’s games from DraftKings Network analysts.

To see all DraftKings betting analysis, head over to the DraftKings Network sports betting picks page!

Check out the numerous MLB betting markets available on DraftKings Sportsbook!

Garion Thorne: Top Home Run Props

Picks below! Read Garion’s full betting analysis here: MLB Best Bets: Top Home Run Props for Wednesday 4/22/26

Matt Olson 1+ Home Run (+320)

Moises Ballesteros 1+ Home Run (+720)

Bryan Armetta: Top NRFI Bets

Picks below! Read Bryan’s full betting analysis here: MLB Best Bets: Top NRFI props for Wednesday 4/22/26

Brewers vs. Tigers NRFI (-140)

Yankees vs. Red Sox NRFI (-140)

Brendan O’Sullivan: Cardinals vs. Marlins prediction, pick

Pick below! Read Brendan’s full betting analysis here: St. Louis Cardinals vs. Miami Marlins prediction, pick for MLB on Wednesday 4/22/26

Best Bet: Over 8.5 runs (-112)

DK.Network.Editors

DraftKings promoters may sometimes play on personal accounts in the games that advice is offered on. Personal views on the games and strategies above do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. DraftKings promoters may also deploy different players and strategies than what is recommended above. DraftKings promoters do not have access to any non-public information.