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DraftKings NBA Pick6 Fantasy Basketball Picks Today: Top Picks for 4/21/26

DraftKings NBA Pick6 Fantasy Basketball Picks Today: Top Picks for 4/21/26

Published:

By: Bill Yin

There are only three games on the slate tonight, tipping off at 7 PM EST with the 76ers visiting the Celtics. The Spurs will host the Trail Blazers next at 8, and the night will conclude with the Rockets visiting the Lakers at 10:30 PM EST.

There are plenty of opportunities to get involved in the action this evening. One of the more unique features on DraftKings this year is Pick6 Fantasy Basketball!

This article will look at my top Pick6 plays for tonight’s slate. We simply choose whether a player will record more or less of the set statistic. Here are my favorite plays for tonight’s action.


Deni Avdija More Than 23.5 Points

Avdija recorded a blistering 30 points on 12/21 shooting in Game 1, but ultimately could not lead his team to a victory. Avdija played 39 minutes and was -12 in the defeat, but there was little that could be done to counter Victor Wembanyama’s playoff debut, during which the French phenom went for 35 points on 13/21 shooting alongside two blocks.

It’s clear that Avdija will continue getting huge minutes and will put up a ton of shots. The efficiency may be ugly as he’ll look for ways around, not through, the outstretched reach of Wembanyama, but he should get enough volume and minutes that he’ll reach 23.5 points.


Jrue Holiday More Than 15.5 Points

It’s not encouraging to see a 4/15 shooting performance and then decide to expect More out of Holiday, but the truth is that he’s not a 4/15 shooter. He went 1/7 from downtown and had a terrible night shooting, but he still played 36 minutes and he’s clearly Portland’s second best player in terms of his impact on the court. Similar to Avdija, I’m not expecting Holiday’s shooting to be world-class given the type of defense he’ll be up against, but the 36 minutes and 15 FGA was a good sign for his scoring ceiling moving forward.


LeBron James Less Than 24.5 Points

James’ days of solo carrying are over – for the most part. The veteran superstar is still capable of some huge nights offensively, but big minutes will wear on him more than they ever have before. In the Lakers’ Game 1 victory over the Rockets, James logged 38 minutes and put up 19 points on 9/15 shooting. I’m anticipating James falling short of 24.5 points once again, as his role is clear on this team without Luka Doncic and Austin Reaves; he’s their de-facto point guard, as evidenced by his game-high 13 assists. He dismantled Houston through his playmaking, and I’m expecting more of the same tonight. James was also a game-high +11 in that game.


What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of at least two players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.


How to Play DraftKings Pick6

Create a Pick Set

Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you cannot pick the same player twice and you must select players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.


Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!

Bill joined DraftKings as a writer and editor in August of 2024, where he has been primarily covering the NBA. He earned his bachelor’s degree in English at Rutgers University and has transitioned into sports coverage after working in academic publishing. He is based in NYC and has previously contributed to FantasySixPack and Razzball.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.