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San Antonio Spurs vs. Philadelphia 76ers prediction, pick for Monday 4/6/26

San Antonio Spurs vs. Philadelphia 76ers prediction, pick for Monday 4/6/26

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By: Brendan O'Sullivan

The Spurs and 76ers match up for the second time this season, with San Antonio winning the first round on the road.

San Antonio is an 8.5-point favorite and -310 on the moneyline, while Philadelphia is +250 on DraftKings Sportsbook. The over/under is set at 234.5 points.

Here’s a preview, prediction and pick for Monday’s Spurs vs. 76ers matchup.

Spurs vs. 76ers prediction, preview

The Spurs are one of the most fun teams to watch—unless you’re rooting against them. Then, they may be irritating because they’re one of the best teams in the league. Victor Wembanyama is a legit MVP candidate in addition to being the best defender in the NBA.

Monday’s matchup with the 76ers should be fun considering Philadelphia is fully healthy. Tyrese Maxey and Joel Embiid are ready to go, and Paul George is playing his best basketball post-suspension. With just a few games remaining, both teams are playing for playoff positioning.

The Spurs are the No. 2 seed in the West, three games behind the Thunder. It’s unlikely they overtake Oklahoma City, but it’s technically not impossible yet.

Meanwhile, the 76ers are fighting to maintain a playoff spot. They’re 43-35, just two games behind the fifth-seeded Hawks and two games ahead of the 10th-seeded Heat. Philadelphia cannot fall out of the Play-In Tournament, but the next few games will decide their first round matchup.

Spurs vs. 76ers pick, best bet

Although the 76ers have their stars healthy, it doesn’t seem like it’ll be enough to overcome Wembanyama and the Spurs. San Antonio has lost just three times since the start of February (twice to Denver and once to New York).

Especially at home, the Spurs will likely win by double digits.

Best bet: San Antonio Spurs -8.5 (-105)

I am a promoter at DraftKings and am also an avid fan and user (my username is osullivanb255) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.