Looking for the best March Madness parlays today? Friday’s Sweet 16 slate tips off at 7:10 p.m. ET with four games, giving bettors a high-stakes board to work with. From spreads to totals and a few higher-risk angles, there are plenty of ways to build out a strong card on DraftKings Sportsbook.
Below, we’ve highlighted a mix of favorites, underdogs, and game scripts to target across tonight’s Sweet 16 matchups. Browse the picks and add your favorites directly to your bet slip.
Best NCAA Tournament Parlays for March 27, 2026
Below are today’s featured March Madness parlays available on DraftKings Sportsbook. Click “Add to Bet Slip” to place your wager instantly in the DraftKings app. These March Madness parlays focus on spreads, totals, and game scripts across Friday’s Sweet 16 matchups.
Barstool Sports Sweet 16 Spread Picks
Ride with the PMT crew as they pick their favorite Friday CBB lines!
- #2 Iowa State -4.5 (vs TENN)
- #2 UConn -2.5 (vs MSU)
- #4 Alabama +9.5 (vs MICH)
Sweet 16 Moneyline Parlay Picks
Back these four teams to make one more big step towards Indianapolis!
- #1 Duke to Win (vs St. Johns)
- #1 Michigan to Win (vs Alabama)
- #3 Michigan State to Win (vs UConn)
- #6 Tennessee to Win (vs Iowa State)
Sweet 16 First 4 Minute Winner Parlay
After the first 4 minutes of play, take these schools to have the lead!
- #1 Duke to Win First 4 Min. (vs SJU)
- #1 Michigan to Win First 4 Min. (vs ALA)
- #2 UConn to Win First 4 Min. (vs MSU)
- #2 Iowa State to Win First 4 Min. (vs TENN)
ESPN’s Joe Fortenbaugh Sweet 16 Parlay Picks
ESPN’s Joe Fortenbaugh picks these lines for the Sweet 16!
- #2 UConn -2.5 (vs Michigan State)
- #6 Tennessee +4.5 (vs Iowa State)
- SJU vs DUKE: Under 140.5 Points
March Madness Sweet 16 Game Total Parlay
Cheer on each teams’ offensive prowess to shine in these Friday matchups!
- SJU @ DUKE: Over 140.5 Points
- ALA @ MICH: Over 172.5 Points
- MSU @ UCONN: Over 136.5 Points
- TENN @ ISU: Over 139.5 Points
Check out our NCAA Tournament coverage with picks, predictions for every game on DraftKings Network!
#1 Duke Same Game Parlay Picks
- #1 Duke -6.5 (vs St. Johns)
- Cameron Boozer 40+ Pts + Reb + Ast
- Isaiah Evans 15+ Points
- Dame Sarr 2+ Made Threes
Rico Bosco’s Longshot Moneyline Parlay Picks
- #3 Michigan State to Win (vs UConn)
- #4 Alabama to Win (vs Michigan)
- #6 Tennessee to Win (vs Iowa State)
Check out all our parlays for every sport on the DraftKings Network Parlay Page!
