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Opening Odds for Michigan State Spartans vs. UConn Huskies in March Madness 2026 Sweet 16

Opening Odds for Michigan State Spartans vs. UConn Huskies in March Madness 2026 Sweet 16

Sports Betting Picks College Basketball 2026

Published:

By: Brendan O'Sullivan

The Spartans are back in the Sweet 16 for the second consecutive season and have a date with No. 2 UConn. No. 3 Michigan State’s offense was on fire against No. 14 North Dakota State in the first round. It then defeated No. 6 Louisville in the second round to advance past the first weekend. Jeremy Fears Jr. has been marvelous, recording 11 and 16 assists across the first two games.

Alex Karaban’s career high 27 points lifted the Huskies past No. 7 UCLA in the second round. It wasn’t the prettiest win, but UConn’s offense picked up in the second half.

Michigan State vs. UConn opening odds

The Spartans open as 1.5-point favorites on DraftKings Sportsbook, with the Huskies listed at +100 on the moneyline. The points total is set at 140.5.

This game will take place on Friday, March 27 at the Capital One Arena in Washington, D.C.

Brendan O'Sullivan

I am a promoter at DraftKings and am also an avid fan and user (my username is osullivanb255) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.