Searching for the best March Madness parlays today? Saturday’s NCAA Tournament slate tips off at 12:10 p.m. ET with 16 games on the schedule. That creates plenty of opportunities for player props, spreads, and longshot bets on DraftKings Sportsbook. Browse today’s featured picks below and add your selections directly to your bet slip.
Best NCAA Tournament Parlays for March 21, 2026
Below are today’s featured March Madness parlays available on DraftKings Sportsbook. Click “Add to Bet Slip” to place your wager instantly in the DraftKings app. These March Madness parlays focus on spreads, totals, and game scripts across Saturday’s Round of 32 matchups.
NCAA Tournament Sweet 16 Advancement Parlay
- #1 Duke to Win (vs TCU)
- #4 Arkansas to Win (vs High Point)
- #5 Vanderbilt to Win (vs Nebraska)
- #6 Louisville to Win (vs Michigan St)
March Madness Underdog Moneyline Parlay
- #6 Louisville to Win (vs Michigan State)
- #12 High Point to Win (vs Arkansas)
NCAA Tournament Game Total Parlay
- VAN vs NEB: Over 146.5 Points
- LOU vs MSU: Over 150.5 Points
- HPU vs ARK: Over 169.5 Points
- TCU vs DUKE: Over 138.5 Points
#1 Michigan Same Game Parlay Picks
- Michigan to Win by 10+ (vs Saint Louis)
- Yaxel Lendeborg 15+ Points
- Elliot Cadeau 10+ Points
- Aday Mara 8+ Rebounds
Rico Bosco’s Round of 32 Parlay Picks
- #2 Houston to Win (vs Texas A&M)
- #3 Michigan State to Win (vs Louisville)
- #9 TCU +11.5 (vs Duke)
- HPU vs ARK: Over 80.5 1H Points
Check out our NCAA Tournament coverage with picks, predictions for every game on DraftKings Network!
Duke & Nebraska Spread + Total Parlay
- #1 Duke to Win (vs TCU)
- TCU vs DUKE: Over 138.5 Points
- #4 Nebraska to Win (vs Vanderbilt)
- VAN vs NEB: Over 146.5 Points
March Madness Texas-Based Upset Parlay
- #9 TCU to Win (vs Duke)
- #11 Texas to Win (vs Gonzaga)
#1 Duke Same Game Parlay Picks
- Duke to Win by 10+ (vs TCU)
- Cameron Boozer 25+ Points
- Isaiah Evans 15+ Points
- Cayden Boozer 10+ Points
ESPN’s Steven Stafford March Madness Parlay Picks
- #11 Texas +6.5 (vs Gonzaga)
- #9 TCU to Win (vs Duke)
- #3 Michigan State to Win (vs Louisville)
March Madness First Half Moneyline Parlay Picks
- #11 VCU to Win 1st Half (vs Illinois)
- #12 High Point to Win 1st Half (vs Arkansas)
NCAA Tournament SEC Moneyline Parlay
- #4 Arkansas to Win (vs High Point)
- #4 Alabama to Win (vs Texas Tech)
- #5 Vanderbilt to Win (vs Nebraska)
- #7 Kentucky to Win (vs Iowa State)
Check out all our parlays for every sport on the DraftKings Network Parlay Page!
