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College Basketball Best Bets: Top March Madness Picks in The CBB Board Betting Group for Saturday 3/21/26

College Basketball Best Bets: Top March Madness Picks in The CBB Board Betting Group for Saturday 3/21/26

Sports Betting Picks College Basketball 2026

Published:

By: DK.Network.Editors

DraftKings analysts break down their favorite NCAAM best bets with full betting analysis in “The CBB Board” betting group on DraftKings Sportsbook for Saturday’s March Madness matchups.

Join The CBB Board betting group now!

RELATED Best March Madness upset predictions for Saturday 3/21/26

For up-to-date NCAAM betting information and data, check out both the DraftKings Sportsbook betting splits page and the DraftKings Sportsbook player props page!

Brendan O’Sullivan

Parlay:

Michigan State -4.5 (vs Louisville)

Duke -11.5 (vs TCU)

Texas +6.5 (at Gonzaga)

Odds: +575

Tail this bet by clicking the odds above!

Analysis:

Blake Krass

Parlay:

Michigan State Moneyline (vs Louisville)

Illinois -4.5 (vs VCU)

Odds: +103

Tail this bet by clicking the odds above!

Analysis:

DK.Network.Editors

DraftKings promoters may sometimes play on personal accounts in the games that advice is offered on. Personal views on the games and strategies above do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. DraftKings promoters may also deploy different players and strategies than what is recommended above. DraftKings promoters do not have access to any non-public information.