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Opening odds for Duke Blue Devils vs. Siena Saints in March Madness 2026 First Round

Opening odds for Duke Blue Devils vs. Siena Saints in March Madness 2026 First Round

Published:

By: Sean Barnard

The full NCAA Tournament bracket has been established, and the stage is set for this year’s iteration of March Madness. Facing off in the East Region of the bracket, Duke will enter as the top seed in the entire tournament and face off with 16th-seeded Siena.

Duke Blue Devils vs. Siena Saints Opening Odds

Looking at the odds on DraftKings Sportsbook, Duke opens as a 26.5-point favorite over Siena with the game total set at 136.5.

Duke finished the season as the top-ranked team in the AP Poll and successfully won the ACC Tournament to maintain momentum. The Blue Devils hold a 32-2 overall record, with Cameron Boozer making a strong case for the best player in the country all season. There are some injury concerns on this roster, but the Blue Devils earned the outright top seed for a reason.

The Siena Saints earned their trip to the NCAA Tournament by winning the Metro Atlantic Athletic Conference (MAAC). Gerry McNamara’s squad went 23-11 this season, which marks the program’s best record since 2009-10. This also marks Siena’s first time back in the NCAA Tournament since this same season.

The winner of this matchup will play the winner of 8-seeded Ohio State vs. 9-seeded TCU in the round of 32. The opening two rounds are fairly close to home for the Blue Devils, as they will be facing off in Greenville, South Carolina.

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