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Real Madrid vs. Benfica prediction, pick for Wednesday 2/25/26

Real Madrid vs. Benfica prediction, pick for Wednesday 2/25/26

Published:

By: Ciaran Doyle

The second leg of the playoff round between Real Madrid and Benfica takes place on Wednesday in Madrid. Real Madrid narrowly won the first leg 1-0 and take a narrow lead back home for the second leg. Can Benfica make a comeback, or will Real Madrid coast into the Round of 16?

Madrid are -185 favorites on the moneyline, while a draw is available at +360. Fancy a Benfica upset? They are +450 on the moneyline on DraftKings Sportsbook.

Real Madrid vs. Benfica Prediction, Pick

This bet can be found under the “Match Parlays” tab. These teams will play each other for the third consecutive time in the Champions League.

Benfica won a dramatic game 4-2 in the last game of the League Phase to get themselves into the playoff round. These teams were drawn against each other in the playoff, and Real Madrid won the first leg 1-0 in Portugal. We’ve seen two very different games so far, but I have a feeling the second leg of this playoff will be similar to the first.

For the first time, Benfica will head to the Bernabéu. It’s a daunting place to play when you need to win. Benfica struggled on the road in the league phase, losing three times and winning one. In all three of the losses, the Portuguese side failed to score. On the flip side, Real Madrid defended their home stadium well in the League Phase, winning three of their four home games.

Even though Benfica are trailing and need a goal, I think Madrid will ultimately win this game while keeping a clean sheet and advancing to the Round of 16.

Best Bet: Real Madrid Win to Zero (+185)

Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.