Week 17 of the 2025-26 NFL season continues with a great Sunday Night Football matchup between the Chicago Bears and San Francisco 49ers. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this season is Pick6 Fantasy Football!
Here are my top Pick6 plays for Sunday Night Football.
Caleb Williams More Than 1.5 Touchdown Passes
Caleb Williams is starting to look more and more like a worthy No. 1 overall pick. He is still not consistent enough to be named among the top quarterbacks in the NFL, but he has learned how to win in the NFL. Williams has been fantastic down the stretch in games, leading his team on big drives whenever they need him to. The Bears control their own path to the NFC North title, and this would be a massive win over another team competing for an NFC playoff spot. Williams should rise to the occasion and throw for at least two touchdowns in this game. Williams has thrown for multiple scores in three straight games ahead of this matchup. The 49ers rank 23rd in defensive EPA/dropback and 24th in defensive dropback success rate this season. Williams should make them pay with a couple of passing scores in what should be a high-scoring game on Sunday night.

Jauan Jennings More Than 0.5 Rushing + Receiving Touchdowns
Jauan Jennings has been the 49ers’ top wide receiver over the past few weeks. George Kittle has been at his best from the tight end position, but in the wide receivers area, Jennings has been Brock Purdy’s go-to guy. It has been a strange season for the 49ers at the wide receiver position and Jennings has provided much-needed consistency. The 49ers’ two leading receivers this season are Kittle and Christian McCaffrey. However, Jennings leads the way among the wide receivers. He has specifically been a touchdown machine over the last couple of months. Jennings has seven touchdowns in his past seven games, only failing to score in one of those seven games. The Bears rank 22nd in the NFL in defensive success rate, so Purdy should be able to keep the chains moving and get scoring chances against this defense. When the team gets into scoring position, Purdy will continue to look to his hottest red-zone target, Jauan Jennings. This is a big game for the 49ers, and Jennings should make it five straight games with a score.

Luther Burden III More Than 45.5 Receiving Yards
Luther Burden III is making his return for the Bears after missing last week’s game against the Packers. Burden was sorely missed, as he had led the team in receiving the two previous games. With Rome Odunze injured, Burden was starting to turn into Caleb Williams’ top target. Burden should return to form against the 49ers after only missing one game. Burden has had at least 46 receiving yards in four of his past six games ahead of this matchup. With Odunze still sidelined, Burden should maintain a high target share. He should be able to get open and make plays against a poor 49ers secondary. San Francisco ranks 23rd in defensive EPA/dropback and 24th in defensive dropback success rate this season. The rookie wide receiver should pick up where he left off against this vulnerable defense and go for at least 46 yards through the air.

What is DraftKings Pick6?
Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.
How to Play
Create a Pick Set
Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.
Enter an Amount
Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.
Sweat Your Picks
When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.
Compete for Prizes
Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.
Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!