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George Kittle best prop bet for 49ers at Colts on Monday 12/22/25

George Kittle best prop bet for 49ers at Colts on Monday 12/22/25

Indianapolis Colts Sports Betting Picks NFL DraftKings Sportsbook Insights

Published:

By: Alex Hunter

The 49ers are visiting the Colts on Monday. On DraftKings Sportsbook, San Francisco is favored by 4.5 points and this game carries a total of 45.5 points.

Below, I have featured my favorite George Kittle prop to consider from this contest.

Best George Kittle Prop Bets on DraftKings Sportsbook

George Kittle O 23.5 Yards Longest Reception (-110)

Brock Purdy is healthy again for the 49ers, which is great news for Kittle. These two players have played five games together this season and in these contests, Kittle is averaging 5.6 catches for 65 yards per game. The tight end is seeing a target on a team-high 26% of his routes and Kittle is averaging an elite 2.52 yards per route run with Purdy active this season, which is a huge increase from the 1.42 yards per route run he is averaging with Purdy inactive.

Kittle has hauled in a pass of at least 24 yards in four of these five games with Purdy starting and that lone outlier is a game that Kittle exited after only playing 27.6% of the snaps. Now, he is facing a Colts defense that is allowing the eighth-most yards per pass in the league in their last three games (7.5).

Kittle should have one of his best outings of the season in this spot and backing him for over 23.5 yards for his longest reception has a ton of merit Monday.

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Alex Hunter
Alex Hunter is an avid DFS player and sports handicapper, who has been a proud member of the DraftKings Network team since 2020. He is a data-driven analyst, who earned his bachelor’s degree in communications at Worcester State University and has been in the sports content business for nearly a decade, covering the NBA, NFL and PGA TOUR. Alex is a diehard Boston Celtics fan, who loves to be on the golf course when he isn’t grinding lineups or producing content. For all of Alex’s work or if you need any lineup advice, be sure to follow him @Hunta512 on X.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is Hunta512) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.