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Best Tyler Warren Prop Bet for 49ers vs. Colts on Monday 12/22/25

Best Tyler Warren Prop Bet for 49ers vs. Colts on Monday 12/22/25

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By: Ciaran Doyle

Week 16 concludes in Indianapolis on Monday as the 49ers face the Colts.

This game has huge playoff implications in both conferences. San Francisco is still battling for the NFC West crown, while the Colts are realistically fighting for their playoff lives.

The 49ers are 4.5-point favorites for this one, with the Colts listed as +195 underdogs on the moneyline. The points total is set at O/U 45.5 on DraftKings Sportsbook.

Below is my favorite Warren prop bet on DraftKings Sportsbook for Monday’s game.

Best Tyler Warren Prop Bet on DraftKings Sportsbook

It’s truly been a rollercoaster of a season for Colts fans. Philip Rivers is set to make his second start in a row as Indianapolis fights to stay in contention for a Wild Card spot in the AFC.

Tyler Warren struggled in his first game with Rivers, only catching three of six targets for 19 yards. I expect the connection between quarterback and tight end to be much improved on Monday Night Football. It’s clear that Rivers is lacking in arm strength and will not be throwing the ball all over the yard in this one. Instead, expect a heavy dose of Jonathan Taylor and a lot of dinking and dunking in the passing game.

The 49ers defense hasn’t been anything special against the pass this season, ranking 23rd in the NFL while allowing an average of 227.6 yards per game through the air.

Warren will provide a great security blanket in the short passing game, and I would expect him to get even more than six targets in this one. Because of that, I think he gets over this low total. He might not rip off a catch of more than 10 yards, but the volume of targets that are likely to come his way should be enough to get over 38.5 receiving yards.

Under much different circumstances, Warren went over this total nine times earlier in the season. I think he finds a way to do it for the 10th time this season under the lights of primetime.

Best Bet: Tyler Warren Over 38.5 Receiving Yards (-112)

Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.