If you’re looking for 49ers Colts Same Game Parlay picks for NFL Week 16, you’re in the right spot. Below you’ll find several 49ers-Colts parlays that you can easily add to your bet slip by clicking the “Add to Bet Slip” button. Once you do so, you’ll be directed to DraftKings Sportsbook, where you can place your bet. Then, be sure to watch along for tonight’s game on ESPN.
You can view our full complement of parlays and same game parlays on DraftKings Network!
Follow me on Twitter for betting insights, splits, and props on this game @SteveBuchanan
49ers vs. Colts Week 16 Game Odds and Lines
Here are the latest odds and lines for tonight’s Week 16 matchup between the 49ers and Colts!
49ers-Colts Parlay Picks – NFL Week 16
49ers-Colts Same Game Parlay: Stephen A of ESPN likes these props for tonight!
- George Kittle to Score a TD
- Johnathan Taylor 100+ Rushing Yards
- Christian McCaffrey 6+ Receptions
Follow me on Twitter for betting insights, splits, and props on this game @SteveBuchanan
Philip Rivers Same Game Parlay: Back these props for Philip Rivers against the 49ers!
- Philip Rivers 200+ Passing Yards
- Philip Rivers 25+ 1Q Passing Yards
- Philip Rivers 2+ Passing TDs
49ers-Colts Anytime Touchdown Parlay: Back these players to score on Monday Night Football!
- Jonathan Taylor to Score a TD
- Christian McCaffrey to Score a TD
- Michael Pittman Jr. to Score a TD
- Jauan Jennings to Score a TD
49ers Colts 1Q Parlay: Back these 1Q props tonight!
- J. Taylor 10+ 1st Quarter Rush Yards
- C. McCaffrey 10+ 1st Quarter Rush Yards
- M. Pittman Jr. 10+ 1st Quarter Rec Yards
- J. Jennings 10+ 1st Quarter Rec Yards
49ers Same Game Parlay: Back these 49ers props Monday!
- Brock Purdy 250+ Passing Yards
- Christian McCaffrey 60+ Rushing Yards
- George Kittle 60+ Receiving Yards
- Jauan Jennings to Score a TD
49ers Colts Receiving Yard Parlay: Bet this parlay for these players to record 40+ receiving yards tonight!
- George Kittle 40+ Receiving Yards
- Michael Pittman Jr. 40+ Receiving Yards
- Jauan Jennings 40+ Receiving Yards
- Tyler Warren 40+ Receiving Yards
- Christian McCaffrey 40+ Receiving Yards
Want even more action? Check out all of our NFL parlays on DraftKings Network for updated odds and fresh builds.
How to Watch 49ers vs. Colts
Here’s everything you need to know to watch the Week 16 primetime matchup between the San Francisco 49ers and Indianapolis Colts, including kickoff time, TV channel, and streaming options.
Date: Monday, December 22, 2025
Location: Lucas Oil Stadium
Kickoff: 8:15 p.m. ET / 9:15 p.m. CT
TV: ESPN
Streaming: Fubo, Hulu, NFL+, YouTube TV
