Week 16 of the 2025-26 NFL season continues with a great Sunday slate. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this season is Pick6 Fantasy Football!
Here are my top Pick6 plays for the Week 16 Sunday slate.
Quinshon Judkins More Than 0.5 Rushing + Receiving Touchdowns
Quinshon Judkins should be in for a big game against the Bills. Judkins has had a bright rookie season, leading all rookies in rushing yards this season. Last week, his fellow rookie and former Ohio State teammate, TreVeyon Henderson, rushed for 148 yards and two scores against this Bills defense. Judkins should also be able to break some long runs and find the end zone. Buffalo ranks 31st in the NFL in defensive EPA/rush, 30th in rushing yards per game allowed and 32nd in rushing touchdowns per game allowed. The Bills are allowing 1.6 rushing touchdowns per game, and Judkins should capitalize on that porous run defense to find the end zone himself on Sunday.
Rico Dowdle More Than 76.5 Rushing + Receiving Yards
Rico Dowdle is having a great season for Carolina. After starting the season down the depth chart, he took advantage of an injury to Chuba Hubbard and proved himself to be a great running back. He went through a stretch where he was putting up the biggest rushing numbers in the league in the middle of the season. Hubbard came back and took a share of the carries, and Dowdle slowed down a bit as well. However, he has still continued to put up solid numbers, ranking ninth in the league in rushing yards this season.
Dowdle should have a solid game against the Buccaneers on Sunday. The Tampa Bay run defense has not been the same in the second half of the season. In Weeks 1-9, it ranked third in the NFL in defensive EPA/rush and defensive rushing success rate. Since Week 10, it ranks 21st in defensive EPA/rush. Tampa Bay also really struggles defending running backs in the passing game. Tampa Bay is giving up 55.9 receiving yards per game to opposing running backs, almost 10 yards per game more than the next-worst team. Dowdle should be able to break a couple of long runs and get some action in the receiving game to clear this number.
Audric Estime More Than 0.5 Rushing + Receiving Touchdowns
Audric Estime is going to be the primary running back for the Saints this week. After Alvin Kamara and Devin Neal both went down with injuries, New Orleans is forced to turn to the former Bronco. Estime was a fifth-round pick in last year’s NFL Draft and never got a real chance to show what he was capable of in Denver. This game will be Estime’s first NFL game as the primary back and he will look to make the most of it. Luckily for Estime, the Jets rank 26th in the NFL in defensive EPA/rush, 29th in opponent rushing yards per game and 27th in opponent rushing touchdowns per game. Estime should take this opportunity seriously and do everything in his power to produce against the Jets on Sunday. Based on recent performances from the Jets, Estime should be able to find the end zone and score his third career touchdown.
What is DraftKings Pick6?
Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.
How to Play
Create a Pick Set
Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.
Enter an Amount
Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.
Sweat Your Picks
When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.
Compete for Prizes
Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.
Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!
