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Tottenham vs. Slavia Prague prediction, pick for Tuesday 12/9/25

Tottenham vs. Slavia Prague prediction, pick for Tuesday 12/9/25

Published:

By: Charlie Cummings

Tuesday’s loaded UEFA Champions League slate features several crucial matchups for qualification. Tottenham claimed one European trophy last season and is looking to make some noise in the knockout stages. Another win here puts them closer to a spot in the next qualification stage. Meanwhile, Slavia Prague has failed to win any of its five UCL games. They’ll look to play spoiler on Tuesday with their hopes of advancing all but dashed.

Tottenham are -230 favorites to win and +390 to draw at DraftKings Sportsbook, while Prague is +550 on the Moneyline. Let’s dig into a prediction and pick for this Tottenham vs. Slavia Prague match.

Tottenham vs. Slavia Prague prediction, pick

Tottenham certainly don’t come into this game on a good run of form. Their last domestic match, a 2-0 win over Brentford, ended a five-game winless streak. Once again, they’re struggling in the Premier League, sitting in the middle of the table with a 6-4-5 record. Despite their high-profile additions, they’ve failed to rebound from a disappointing 2024/25 campaign.

Their disappointments are not limited to their domestic league. Tottenham have dropped points twice, drawing against AS Monaco and Bodo Glimt. Another disappointing loss to an overmatched Prague side would be a brutal indictment of Tottenham manager Thomas Frank and his squad.

Slavia Prague find themselves in a familiar position. They dominate their domestic league but don’t have the talent or the resources to compete with the bigger UCL sides. There’s some talent here, but they’re always fighting an uphill battle to qualify for the knockout stages. With three points in five games, they’re going to need a minor miracle to sneak into the qualification playoff.

It isn’t easy to see a way through for Prague. Frankly, I’m surprised the Moneyline odds are this close. Even with Tottenham’s poor form and penchant for dropping points, they’d be hard-pressed to find a way to lose this one.

Best Bet: Tottenham Moneyline + Richarlison Anytime Goal Scorer (+150)

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.