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Best Jameson Williams Prop Bet for Cowboys vs. Lions on Thursday 12/4/25

Best Jameson Williams Prop Bet for Cowboys vs. Lions on Thursday 12/4/25

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By: Ciaran Doyle

Thanksgiving football has come and gone, and now we move to Week 14 of the NFL season as the Cowboys face the Lions on Thursday Night Football. Jameson Williams had his best game of the season on Turkey Day in the absence of Amon-Ra St. Brown and will look to have a similar output on Thursday if his fellow wideout can’t go.

The Lions are 3-point favorites for this game, with the Cowboys +140 underdogs on the moneyline. The points total is set at O/U 54.5 on DraftKings Sportsbook.

Below is my favorite Williams prop bet on DraftKings Sportsbook for Thursday’s game.

Best Jameson Williams Prop Bet on DraftKings Sportsbook

Jameson Williams’ outlook for this game very much depends on Amon-Ra St. Brown. If St. Brown can’t go, Williams will likely have another monster performance. If St. Brown does play, expect it to be business as usual in the Lions receiving room. I am banking on the former, and with that I will be taking his over in this one.

Against Green Bay, St. Brown went down in the first quarter. As a result, Williams received season highs in targets, receptions and receiving yards. He caught seven of 10 targets for 144 yards and a touchdown. Williams proved that he can be a true number one wideout without being in the shadow of one of the best receivers in the league. Even if St. Brown does suit up, he’s unlikely to be 100%.

Regardless of who plays, Williams has the potential to go over this total. He has gone over this total four times this season and has eclipsed 100 yards on three occasions. Facing a Cowboys defense that are the third worst in the league against the pass, allowing an average of 251.5 yards per game can’t hurt either. I think Williams will go over this total with ease for the second straight week.

Best Bet: Jameson Williams Over 82.5 Receiving Yards (-112)

Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.