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College Basketball prediction, pick for Louisville vs. Arkansas on Wednesday 12/3/25

College Basketball prediction, pick for Louisville vs. Arkansas on Wednesday 12/3/25

Published:

By: Ryan Wohl

No. 6 Louisville heads to Arkansas to face the No. 25-ranked Razorbacks at 7:15 p.m. ET. The Cardinals have a perfect 7-0 record and will face their second-ranked opponent of the season, and their first since playing Kentucky on November 11. In the past, these two programs have faced each other eight times, with the series standing 4-4. This is the first matchup between the two teams since 2022 and the third in the last 26 years.

Louisville is a -2.5-point favorite with Arkansas being +120 to win this game outright on DraftKings Sportsbook. Here is my best bet for tonight’s Louisville vs. Arkansas matchup.

Louisville vs. Arkansas (7:15 p.m. ET)

Arkansas is 5-2 on the season and is coming off a loss to No. 4 Duke, but both losses were to elite opponents. Star freshman duo Meleek Thomas and Darius Acuff Jr are the Razorbacks’ two best players this season. They both average at least 17 points per game, but Arkansas has a young roster that has struggled against top-tier talent.

Louisville has only three players averaging double-digit points per game, but six players are recording at least nine points. Xavier transfer Ryan Conwell has been their veteran leader and is averaging 20.1 points per game. The Cardinals also have an outstanding freshman in Mikel Brown Jr., who averages 17 points and six assists per game.

Louisville is ranked No. 9 on KenPom, with Arkansas at No. 37. Arkansas has the 48th-highest offensive rating and the 35th-best defensive rating. Louisville averages over eight more points per game than Arkansas and should be able to wear them down, as it has a more experienced roster. Although Lopusville hasn’t had the most challenging schedule yet, they have beaten each opponent by at least eight points this season.

College Basketball Pick: Louisville -2.5 (-110)

Ryan Wohl

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.