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College Basketball prediction, pick for USC vs. Oregon on Tueday 12/2/25

College Basketball prediction, pick for USC vs. Oregon on Tueday 12/2/25

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By: Ryan Wohl

The final matchup of the night, featuring a top 25 team, is No. 24 USC vs. the Oregon Ducks at 10:00 p.m. ET. This is the first Big Ten matchup for both teams this season. Oregon has won the previous five matchups against USC, with the Ducks’ last win against the Trojans coming in February 2022. USC has gone 7-0 to start the season, while Oregon has a 4-3 record.

USC is a -2.5-point favorite with the Ducks being a +124 underdog on DraftKings Sportsbook. Here is my best bet for tonight’s USC vs. Oregon matchup.

USC vs. Oregon (10:00 p.m. ET)

USC has won its last two victories against teams from a major conference. The Trojans beat Seton Hall by two points and Arizona State by 13 points last week at the Southwest Maui Invitational. This season, they have two players, Rodney Rice and Chad Baker-Mazara, averaging 20.3 points per contest. Their third leading scorer, Ezra Ausar, averages 17.3 per game while shooting 69.6 percent from the field.

The Trojans average 91.9 points per game, while the Ducks score 73.7 points per game. Oregon is tied for 268th in points per game. Also on KenPom, Oregon is ranked No. 86, with the 96th-best offense rating and the 90th-best defense. USC is ranked 26th on KenPom and has the 24th-best offensive rating.

Oregon has four players scoring double-digit points, but lacks depth this season. Nate Bittle leads the team with 16.3 points and 7.8 rebounds per game. USC might have the best two players in this game and has the better overall roster than Oregon. Oregon has lost three consecutive games and has struggled when facing tougher competition. Since USC has been in a few close games recently, it is best to get the Trojans to win this game outright at -155 on DraftKings Sportsbook.

College Basketball Pick: USC Moneyline (-155)

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.