After an exciting Thanksgiving and Black Friday schedule, the 2025 NFL season rolls on to the Sunday slate in Week 13. There are plenty of ways to get in on the action. Here’s a look at my favorite player prop bets for this week’s schedule, all of which you can place on DraftKings Sportsbook.
Without further ado, here are three of the best player props for NFL Week 13.
NFL Week 13 Player Props
James Cook Anytime TD (-105)
The Bills’ passing offense is broken at the moment. Buffalo has lost two of its past three games, scoring fewer than 20 points in both of those losses. The offense only works when James Cook is carrying the load. Cook has been fantastic this season, ranking second in the NFL in rushing yards. This is a good matchup for the Bills against the Steelers since the Pittsburgh run defense has been struggling massively the past few weeks. Since Week 7, Pittsburgh ranks 29th in defensive EPA/rush and 28th in defensive rushing success rate. Against that defense in a tough road environment, the Bills should feed Cook early and often. He has scored a touchdown in each of his past two games and should add another score to his season total against the Steelers.
Baker Mayfield 2+ Passing Touchdowns (-118)
Baker Mayfield is taking the field on Sunday despite suffering a shoulder injury last week against the Rams. The good news is that the injury is in Mayfield’s left shoulder rather than his throwing shoulder. While it could cause discomfort for Mayfield, he should be able to make the throws when his team needs him to. This is also a good matchup for the passing attack against the Cardinals. The Arizona pass defense has been struggling as of late, ranking 31st in defensive dropback success rate since Week 8. Whenever the Buccaneers get into scoring range, they should rely on Mayfield and the passing game. He should throw for at least two scores against this struggling Cardinals defense.
Jaxon Smith-Njigba Longest Reception o28.5 Yards (-110)
Jaxon Smith-Njigba is having an unbelievable season for the Seahawks. Seattle had confidence that Smith-Njigba could be a legitimate WR1 and decided to trade DK Metcalf before the season. The young wideout has since risen to the occasion and exceeded any expectations put upon him. He leads the NFL in receiving yards by a significant margin and has been a deep-ball master since being paired with Sam Darnold. Smith-Njigba has 21 catches of 20+ yards and eight catches of 40+ yards, both leading the NFL. JSN has also hauled in a catch of at least 30 yards in eight of 11 games this season. Two of the three games in which he didn’t have a 30-yard catch came against the NFL’s two best defenses, the Rams and the Texans. He should make a catch of at least 29 yards in this game against the Vikings.
