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Clemson Tigers vs. South Carolina Gamecocks prediction, pick for Saturday 11/29/25

Clemson Tigers vs. South Carolina Gamecocks prediction, pick for Saturday 11/29/25

Published:

By: Blake Krass

The South Carolina Gamecocks host the Clemson Tigers for a Week 14 matchup on Saturday afternoon. Kickoff is scheduled for 12:00 p.m. ET in Columbia, South Carolina.

The Gamecocks are listed as 2.5-point home favorites on DraftKings Sportsbook, with the game’s total set at 46.5 points. Below is my full preview, prediction, and best bet for this matchup between these two out-of-conference rivals.

Clemson vs. South Carolina prediction, preview

Clemson Preview

It has been a terribly disappointing season for Clemson. The Tigers entered the season as odds-on favorites to win the ACC, and many considered them serious national title contenders. Clemson lost the season opener to LSU and never recovered as a team. Cade Klubnik was very underwhelming in a season where he was a preseason Heisman favorite, and the defense was nowhere near the standard that had been set at Clemson over the past decade. In a relatively weak ACC, Clemson has not been able to consistently turn in good performances. They limped their way to six wins to become bowl eligible, so this game’s only significance is bragging rights against their in-state rivals.

South Carolina Preview

It has also been a disappointing season for the Gamecocks. Just like Clemson, South Carolina entered the season with a Heisman candidate at quarterback and College Football Playoff aspirations. Unfortunately, poor offensive line play, incompetent offensive coaching, and a lack of skill position weapons cost the Gamecocks. South Carolina has been close to pulling off a couple of major upsets, against Alabama and Texas A&M, but ended up finishing conference play with just one SEC win. The Gamecocks are out of bowl contention with just four wins, but they would love to take down their rivals to close out the season.

Clemson vs. South Carolina pick, best bet

My best bet for this game is for South Carolina to cover as 2.5-point favorites. Both of these teams have had bad seasons, but there is a major difference in the level of competition that they have faced. The Gamecocks rank fourth in the nation in strength of schedule, while Clemson ranks 71st. Despite having two fewer wins, South Carolina ranks nine spots higher than Clemson in strength of record. Between the two offenses and two defenses featured in this game, the South Carolina defense is the best unit on the field. Despite that tough schedule, the Gamecocks rank 21st in the nation in defensive EPA/play. They should be able to shut Clemson down, just like last season when the Tigers scored just 14 points in a home loss.

The South Carolina offense was the team’s issue all season, but it has seen a real boost since making a change at offensive coordinator. The Gamecocks fired Mike Shula, and the new play-calling boosted the offense significantly. Despite blowing that game in devastating fashion, South Carolina scored 30 points on the road against No. 3 Texas A&M. Then, last week, they scored 51 points against a Coastal Carolina team that had been playing quite well. With more rollouts and quick passes for LaNorris Sellers, the offense looks much more explosive. South Carolina is the better team on both sides of the ball at the moment and has the home-field advantage. They should win this rivalry game and cover the short spread.

Best Bet: South Carolina -2.5 (-115)

Blake Krass has contributed to DraftKings since 2024, and is a content creator with a specialty in sports betting. Blake primarily focuses on college football and NFL coverage but will also be covering college basketball, the NBA, MLB and more. Prior to arriving at DK, Blake was a sports betting writer for The Action Network.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.