If you’re looking for Panthers 49ers Same Game Parlay picks for NFL Week 12, you’re in the right spot. Below you’ll find a number of Pathers Niners parlays that you can easily add to your bet slip by clicking the “Add to Bet Slip” button. Once you do so, you’ll be directed to DraftKings Sportsbook, where you can place your bet. Then, be sure to watch along for tonight’s game on ESPN.
You can view our full complement of parlays and same game parlays on DraftKings Network!
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Panthers vs. 49ers Week 12 Game Odds and Lines
Here is the latest odds and lines for tonight’s Week 12 matchup between the Panthers and 49ers!
Panthers-49ers Parlay Picks – NFL Week 12
Panthers 49ers Anytime Touchdown Parlay: Back these players to reach the end zone Monday night!
- Christian McCaffrey to Score a TD
- Tetairoa McMillan to Score a TD
- George Kittle to Score a TD
Follow me on Twitter for betting insights, splits and props on this game @SBuchanan24
Panthers 49ers Same Game Parlay: Back both Christian McCaffrey and Rico Dowdle to have big nights on Monday!
- Christian McCaffrey 120+ Rush + Rec Yards
- Rico Dowdle 90+ Rush + Rec Yards
- Christian McCaffrey to Score 2+ TDs
- Rico Dowdle to Score a TD
San Francisco 49ers Parlay: Like the 49ers tonight? Back them to win along with some player props!
- SF 49ers to Win (vs CAR)
- Christian McCaffrey 130+ Rush + Rec Yards
- Brock Purdy 2+ Passing TDs
- George Kittle to Score a TD
Panthers 49ers 1Q Parlay: Bet these players to record 2+ 1Q receptions tonight!
- Christian McCaffrey 2+ 1Q Receptions
- Tetairoa McMillan 2+ 1Q Receptions
- George Kittle 2+ 1Q Receptions
Panthers 49ers Passing Parlay: Back these props for both Bryce Young and Brock Purdy in tonight’s Monday Night Football game!
- Brock Purdy 250+ Passing Yards
- Bryce Young 250+ Passing Yards
- Brock Purdy 2+ Passing TDs
- Bryce Young 2+ Passing TDs
Want even more action? Check out all of our NFL parlays on DraftKings Network for updated odds and fresh builds.
How to Watch Panthers vs. 49ers
Here’s everything you need to know to watch the Week 12 primetime matchup between the Carolina Panthers and San Francisco 49ers, including kickoff time, TV channel, and streaming options.
Date: Monday, November 24, 2025
Location: Levi’s Stadium, Santa Clara, CA
Kickoff: 8:15 p.m. ET / 9:15 p.m. CT
TV: ESPN
Streaming: Fubo, Hulu, NFL+, YouTube TV
