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LSU Tigers vs. Western Kentucky Hilltoppers prediction, pick for CFB Week 13 on Saturday 11/22/25

LSU Tigers vs. Western Kentucky Hilltoppers prediction, pick for CFB Week 13 on Saturday 11/22/25

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By: Dan Johnson

Tiger Stadium gets weird in November when the stakes are more pride than banners. LSU walks in 6–4 with an interim coach, a top-20 scoring defense, and an offense still trying to remember what explosive felt like. Western Kentucky shows up 8–2 with an Air Raid label, a 31.5-points-per-game resume, and zero Power Four data points. It’s SEC athletes versus C-USA timing, and the board is daring you to believe the gap isn’t as big as the helmets. The question is less who wins? than how violent does the math get? Below is my prediction for CFB Week 13’s football game between the LSU Tigers and the Western Kentucky Hilltoppers.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

LSU vs. Western Kentucky prediction, preview

WKU’s offense is the selling point, but the context matters. They throw for 296.1 yards per game at 7.6 yards per attempt and live on 47.5% third-down conversions, which is legit. Maverick McIvor and Rodney Tisdale Jr. have combined for 2,922 yards at over 7.5 per attempt with 21 touchdowns and eight picks, spreading to Matthew Henry, K.D. Hutchinson, and Noah Meyers. The run game averages 4.3 yards per carry and supplies real red-zone beef with La’Vell Wright and George Hart scoring 12 times. But all that came against C-USA defenses. Now they walk into a unit allowing only 19.3 points and 329.1 yards per game, with opponents stuck around 198 passing and 130 rushing. LSU ranks top ten nationally in red-zone defense by score rate, allowing just 70.4% of trips to produce points, and has 12 interceptions on the season. Air Raid volume is fine; in Baton Rouge you need answers when windows shrink and safeties actually drive on the ball.

LSU’s offense won’t scare anyone on paper, but the matchup gives it room. They sit at 23.8 points and 346.6 yards per game, with 240.2 through the air and just 106.4 on the ground. Garrett Nussmeier is accurate at 67.4% completions, but his 6.7 yards per attempt reflect a scheme that’s more controlled than explosive. The backfield committee of Caden Durham and Harlem Berry runs efficiently, near 4.8 and 5.0 per carry, yet hasn’t turned the Tigers into a march-down-your-throat outfit. Western Kentucky is the antidote to that slog. The Hilltoppers allow 398.8 yards per game, including 175.1 rushing, and have already surrendered 49 runs of ten plus yards and 30 passes of twenty plus. They produce only 1.2 sacks and 5.2 tackles for loss per game, which is bottom-tier. LSU won’t suddenly look like the 2019 edition, but an offense that usually needs twelve plays to score only has to be competent to churn out double-digit drives here.

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Western Kentucky vs. LSU pick, best bet

The counter is WKU’s red-zone witchcraft and game theory. They give up yards by the acre but only 23.1 points per game because their red-zone touchdown rate allowed sits at 37.8%, fourth nationally. That dovetails with an LSU offense that isn’t finishing drives, converting just 39.4% on third down and often settling for Damian Ramos, who is twenty of twenty-four on field goals. If WKU can stay structurally sound between the twenties and keep this a field-goal game instead of a touchdown game, their own passing volume and 7.6 yards per attempt can keep LSU’s defense on the field longer than it likes. Add in a Hilltopper offense running about 72.5 snaps per game and you can at least sketch the dog covering because LSU never hits the accelerator.

But the hidden pieces still lean toward a grind rather than a track meet. WKU is -4 in turnover margin and piles 63.4 penalty yards per game, living near the bottom ten nationally in flags. LSU is +6 in turnover margin, more disciplined in penalty yardage, and owns a real edge in coverage and tackling. Neither team plays with true tempo; LSU runs about 66 snaps per game and holds the ball roughly 31 minutes, while WKU hovers just over 30. That’s not the profile of a game that naturally explodes past fifty without serious help from busted coverages or special-teams chaos.

The spread at -22.5 invites you to argue about style points and motivation, but the total at 50.5 is where I’d rather plant a flag. This feels more like a mid-forties game than something flirting with sixty; LSU’s defense is too good, WKU’s step up in class is too steep, and the Tigers’ offense is too methodical to keep stacking quick touchdowns. I expect LSU to lean run-heavy with Durham and Berry, let Nussmeier live in controlled concepts to avoid WKU’s turnover spikes, and trust the front seven to slowly choke the Air Raid into checkdowns and field goals. Hilltopper yards will come; Hilltopper touchdowns will not.

I’m on the under 50.5 and would still ride it down to 48.5; call it LSU 31, Western Kentucky 13, with the Tigers’ defense and red-zone math quietly dragging everything below the number.

Best bet: LSU vs. WKU u50.5 total points (-105)

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Dan Johnson has been an editor, writer, and analyst for DraftKings and DraftKings Network since 2024. He’s previously held editorial posts at The Paris Review, Macmillan Publishers, Bedford/St. Martin’s Press, ASSIGNMENT Magazine, and FantasySixPack. You can find his various editorial work & writing (sports-related and non-) at all of the above.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is thegreatdansby9) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.