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DePaul Blue Demons vs. Northwestern Wildcats prediction, pick for NCAAM on Friday 11/14/25

DePaul Blue Demons vs. Northwestern Wildcats prediction, pick for NCAAM on Friday 11/14/25

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By: Dan Johnson

Wintrust’s lights throw a cool glow over a city rivalry that never feels neutral. Northwestern crosses town for its first road test at 8:30 p.m. ET on truTV, and the building will reward poise, glass work, and half-court discipline. Below is my preview, prediction, and pick for tonight’s college basketball game between the DePaul Blue Demons and the Northwestern Wildcats.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

DePaul vs. Northwestern prediction, preview

DePaul gets the crowd and the rims it knows; Northwestern brings a defense that’s traveled three games strong and an offense humming on simple reads. The line sits in the mid-single digits, the total in the low 140s, and the opening five minutes should tell us if pace tilts to the Wildcats’ liking. I think it does.

Northwestern’s last run-out wasn’t noise; it was architecture. The Wildcats shredded Cleveland State 110–63 by shooting 60.3% from the floor, drilling 11 of 21 from deep, and stacking 26 assists to only seven turnovers. The ball never stuck, the wings cut hard, and the second unit kept the throttle down with a 40–28 rebounding edge and a 52–26 paint margin. Nick Martinelli led with 21, Arrinten Page added 17 and nine, and the stat template—clean shooting, shared creation, and volume on the glass—looked repeatable, not fragile. That’s the shape that wins possession games in November gyms.

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Northwestern vs. DePaul pick, best bet

Matchup math favors the Wildcats’ patience. They just won a game on passing and pace control, not shot-making luck; 24 of their 41 makes vs. Cleveland State were assisted before garbage time, and the rotation handled pressure without coughing possessions. DePaul’s path is volatility: win the turnover battle, punch second-chance points, and leverage a lively home crowd. The counterpoint lives in last year’s profile—Northwestern went 2–9 on the road—so you have to price some early jitters in a first road spot. But style is balm: Collins’ group leans half-court, values the ball, and punishes undisciplined closeouts with corner threes and slot cuts. That travels as well as any scheme in a crosstown gym.

I’m laying the 4.5 with the Wildcats. Northwestern should win the shot margin, own the middle eight, and turn DePaul’s turnover/FT slippage into separation.

Final score: Northwestern 74, DePaul 63.

Best bet: Northwestern -4.5 (-105) vs. DePaul

Tail it with me in the DKN Betting Group here!

Dan Johnson has been an editor, writer, and analyst for DraftKings and DraftKings Network since 2024. He’s previously held editorial posts at The Paris Review, Macmillan Publishers, Bedford/St. Martin’s Press, ASSIGNMENT Magazine, and FantasySixPack. You can find his various editorial work & writing (sports-related and non-) at all of the above.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is thegreatdansby9) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.