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2025 NFL Week 10 predictions, picks, best bets, expert analysis

2025 NFL Week 10 predictions, picks, best bets, expert analysis

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By: Blake Krass

There are some great games on the NFL Week 10 slate as the regular season enters its second half. With plenty of ways to get in on the action on DraftKings Sportsbook, this is a look at my best bets for NFL Week 10.

NFL Week 10 Best Bets

Ravens 1H -2.5 (-122) vs. Vikings

The Ravens look like a force to be reckoned with once again. After a slow start to the season paired with an injury to Lamar Jackson, the Ravens need to be nearly flawless the rest of the way to get into the postseason. They have won two straight games, and the offense looked elite last week with Jackson back at the helm. This is a matchup in which the Ravens should jump on the Vikings early. In J.J. McCarthy’s three NFL starts, the Vikings are incredibly fortunate to be 2-1. They trailed the Bears 17-6 heading into the fourth quarter, got steamrolled by the Falcons and beat the Lions despite having 0.5 yards per play less than Detroit.

Lamar Jackson is 24-3 in his career against NFC teams and should win this one as well. The Ravens are more talented than the Vikings and have a top-three quarterback in the league. J.J. McCarthy has scraped by for a couple of miraculous wins, but his quarterback play has been quite poor in those games. The Vikings might pull out some more late magic to cover the spread, so I am backing the Ravens to lead by at least a field goal at the half. Jackson and the Ravens should jump out to a big lead and comfortably cover this first-half spread.

Packers ML (-122) vs. Eagles

These are arguably the two best teams in the NFC. However, both have revealed flaws at times this season. The Packers have two bad losses to the Browns and Panthers. The Eagles similarly took a bad loss to the Giants and have been inconsistent offensively. Saquon Barkley has not hit the incredible heights that he hit last season, and the passing game has been far from reliable. Between the two teams, Green Bay is who I trust more. The Packers have played down to their competition at times, but in other games have looked elite on both sides of the ball.

Green Bay ranks third in the NFL in offensive EPA/play and has some elite playmakers on defense. The Eagles’ defense, which was elite last season, ranks 17th in defensive EPA/play. The Packers should be able to move the ball efficiently and get points up on the board in this game. It will be on Jalen Hurts to try to keep up with Jordan Love, and the passing offense has simply not been consistently good this season. Hurts is 3-6 ATS in his career on Monday Night Football. Meanwhile, Jordan Love is 4-1 SU and ATS in night games at Lambeau Field. The Green Bay crowd should be incredible and will its team to a victory.

Six-Point Teaser: Jets +7.5 & Texans +7.5

The Jets opened as favorites against the Browns, but after selling off some key pieces at the trade deadline, the line flipped to make the Browns favorites. The loss of Sauce Gardner will impact the Jets’ defense long-term, but not so much this week. Dillon Gabriel has shown no ability to throw downfield and no receivers have been dangerous on the outside. The Browns’ only two offensive weapons this season have been rookies Harold Fannin and Quinshon Judkins, both of whom enter this game with nagging injuries. Meanwhile, the Jets’ offense is coming off its best game of the season prior to the bye week, and the Jets ended up keeping all of their pieces on that side of the ball. The Jets have the better offense between these two teams, and with Gabriel’s inability to push it down the field, the Jets’ defense is not much of a liability. This is a coin-flip game, so I will happily take the Jets over a touchdown.

For the Texans’ matchup, this is another game in which the home team opened as short favorites, but the line flipped to make them underdogs. It was suspected that Stroud could miss this game after being concussed last week, but once the news became official, the line flipped to make the Jaguars favorites. While Davis Mills is a downgrade from Stroud, the Texans should not be underdogs in this spot. Houston ranks second in defensive EPA/play, while the Jaguars rank 18th. Mills is experienced in this offense and has Nico Collins at full health to throw to. He should be able to piece together a couple of good drives against Jacksonville’s defense, which should be all Houston needs to keep it close against the Jaguars. Jacksonville won the first matchup between these teams by a touchdown, and that game was in Florida. At home, the Texans should be able to keep it within a touchdown once again on the back of their elite defense.

Blake Krass has contributed to DraftKings since 2024, and is a content creator with a specialty in sports betting. Blake primarily focuses on college football and NFL coverage but will also be covering college basketball, the NBA, MLB and more. Prior to arriving at DK, Blake was a sports betting writer for The Action Network.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.