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Chelsea vs. Ajax prediction, pick for Wednesday 10/22/25

Chelsea vs. Ajax prediction, pick for Wednesday 10/22/25

Published:

By: Ciaran Doyle

The 2025/26 UCL league phase continues on Wednesday as Chelsea and Ajax will face each other in London.

Chelsea are -390 favorites on DraftKings Sportsbook for this one, with a draw available at +550. Fancy an Ajax upset? The Dutch side is +900 on the moneyline.

Chelsea vs. Ajax Prediction, Pick

This bet can be found under the “Match Parlays” tab. It’s been a disastrous start to the season for Ajax, and I think things will only get worse for them on Wednesday. The Dutch side finds themselves dead last in the Champions League standings, losing both games while failing to score and conceding six.

First, it was a 2-0 home loss to Inter Milan, not the end of the world. Then, it was a 4-0 road loss to Marseille. Yikes. Things haven’t been great in the Eredivisie, either. They sit in fourth place after nine games, already nine points behind leaders Feyenoord. Five teams in the league have scored more goals than them.

For Chelsea, things are starting to look good. They have won three games in a row in all competitions, beating Benfica, Liverpool and Nottingham Forest. The Blues have only kept four clean sheets in 11 games so far this season, but they don’t face opponents like this in the Premier League every week.

No disrespect to Ajax, but they have fallen to maybe their lowest point in recent seasons. I think it gets worse before it gets better for the Dutch side.

Chelsea lost their opening UCL match to Bayern Munich, but followed that up with a home win against Benfica. They should make it two wins from three on Wednesday, and hopefully they do so while also keeping a clean sheet.

The Pick: Chelsea Win to Zero (+110)

Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.