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Arsenal vs. Atlético Madrid prediction, pick for Tuesday 10/21/25

Arsenal vs. Atlético Madrid prediction, pick for Tuesday 10/21/25

Published:

By: Ciaran Doyle

The 2025/26 UCL league phase continues on Tuesday as Arsenal and Atlético Madrid will face each other in London.

Arsenal are -175 favorites on DraftKings Sportsbook for this one, with a draw available at +310. Fancy an Atlético Madrid upset? The Spanish side is +500 on the moneyline.

Arsenal vs. Atlético Madrid Prediction, Pick

This bet can be found under the “Match Parlays” tab. I am not expecting too many goals in this game, arguably the best matchup on Tuesday’s Champions League slate.

Arsenal have maybe the best defense in Europe right now, while Diego Simeone’s teams are always set up well defensively. Chances in this one will likely be few and far between, but I fancy the Gunners to find a way to score while keeping yet another clean sheet.

In 11 games in all competitions this season, Arsenal have only conceded three goals. The Gunners have won eight times without allowing a goal. They haven’t allowed a shot on goal in their last two matches. Through two games of this season’s UCL League Phase, Arsenal have won both games, scoring four times while conceding none.

Is there a need to say anything else?

Atlético Madrid can score goals, as evidenced by their 16 in nine La Liga games this season. But overall, it hasn’t been a great start to the new campaign. They find themselves in fourth place in the league, eight points behind leaders Real Madrid. In the Champions League, it’s been a decent start, losing to Liverpool 3-2 at Anfield in the first game before beating Eintracht Frankfurt 5-1 at home. They have shown their ability to score goals this season, but on the road against arguably the best defense on the planet right now will prove to be difficult.

Arsenal have found the net in 10 of their 11 games this season, and will likely do so again on Tuesday.

Atlético are no pushovers, especially in Europe, but this Arsenal side should have too much for them on both ends of the pitch.

The Pick: Arsenal Win to Zero (+135)

Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.