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DraftKings Pick6 Picks: Top Plays for Sunday NFL Week 6

DraftKings Pick6 Picks: Top Plays for Sunday NFL Week 6

Published:

By: Blake Krass

Week 6 of the 2025-26 NFL season continues with a great Sunday slate. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this season is Pick6 Fantasy Football!

Here are my top Pick6 plays for the Week 6 Sunday slate.


Puka Nacua More Than 0.5 Rushing + Receiving Touchdowns

Puka Nacua has been one of the best wide receivers in football ever since coming into the league. However, this could be the true breakout season that establishes Nacua in the top tier with the likes of Justin Jefferson and Ja’Marr Chase. Nacua ranked fourth in the NFL in receiving yards in his rookie season, then ranked third in the NFL in receiving yards per game last season, but missed a chunk of games with injuries. This season, he leads the NFL in receptions and receiving yards. He has three touchdowns in his past four games and should score another against the Ravens. Baltimore ranks 30th in defensive EPA/play. The Ravens are still dealing with injuries on defense, and Nacua should have a free-for-all in this game.


Daniel Jones More Than 21.5 Completions

Daniel Jones is having a career-best season in Indianapolis. He needed a change of scenery and is thriving in Shane Steichen’s offense. He is dangerous with his legs, but has also been efficient through the air. Jones ranks third in the NFL in adjusted EPA/play so far this season. Against this Cardinals defense, it should be a pass-heavy approach for the Colts. Normally, this team loves feeding their bell-cow back, Jonathan Taylor. The Cardinals rank in the top eight in the NFL in both defensive EPA/rush and defensive rushing success rate. Meanwhile, they rank 17th in defensive EPA/dropback and 24th in defensive dropback success rate. Jones has gone over 21.5 completions in three out of five games this season, and in what should be a more pass-heavy game for the Colts, he should clear this number again.


Spencer Rattler More Than 21.5 Completions

Spencer Rattler is having a solid start to this season. Rattler had a rough time in his rookie campaign, struggling in his first career starts with the Saints. However, to Rattler’s credit, he had arguably the worst roster in the NFL around him. He was missing Chris Olave, Rasheed Shahid, Taysom Hill and other top targets for long stretches of time. This season, Rattler has been much more efficient and should be feeling confident after picking up the first win of his career against the Giants last week. He ranks 15th out of 24 eligible quarterbacks in EPA+CPOE composite, in the same range as players like Kyler Murray and Justin Herbert. This week, he faces a Patriots defense that ranks 26th in defensive EPA/dropback and 30th in defensive dropback success rate. Rattler is averaging 23.8 completions per game this season and should get over the 21.5 number again versus New England.


What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.

How to Play

Create a Pick Set

Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.


Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!

Blake Krass has contributed to DraftKings since 2024, and is a content creator with a specialty in sports betting. Blake primarily focuses on college football and NFL coverage but will also be covering college basketball, the NBA, MLB and more. Prior to arriving at DK, Blake was a sports betting writer for The Action Network.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.