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Ole Miss Rebels vs. Washington State Cougars prediction, pick for CFB Week 7 on Saturday 10/11/25

Ole Miss Rebels vs. Washington State Cougars prediction, pick for CFB Week 7 on Saturday 10/11/25

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By: Dan Johnson

The air in Oxford feels electric before noon—clear sky, bright sun, and the kind of hullabaloo that only comes with high stakes. Washington State arrives from Pullman carrying three wins, two long flights, and one enormous task. Ole Miss, 5–0 and ranked fourth in the nation, stands poised on the edge of its own momentum, undefeated at home, eyes quietly fixed on Georgia looming next week. The first-ever meeting between these programs doesn’t feel balanced—it feels like collision versus survival. Below is my prediction for CFB Week 7’s game between the Ole Miss Rebels and the Washington State Cougars.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

Ole Miss vs. Washington State prediction, preview

Ole Miss has the nation’s 14th-ranked scoring offense at 40.6 points per game, a machine of rhythm and balance. Trinidad Chambliss has turned Lane Kiffin’s playbook into a runway, throwing for 1,033 yards at 64.4% completion with five touchdowns and just one interception. He’s averaging 10.2 yards per attempt and adds another 266 yards rushing—numbers that reveal a quarterback in full command. Against LSU, he produced 385 total yards and a touchdown, completing 59.0% of passes under heavy duress. Kiffin has leaned on him not as a caretaker but as the axis of identity. When Chambliss controls tempo, Ole Miss averages 8.3 yards per play on first down, forcing defenses to declare early and die quickly.

The running game zips beneath him. Kewan Lacy has 445 rushing yards, eight touchdowns, and a relentless 4.4 yards per carry. He’s hit 20 carries or more in three straight games and handles 68% of red-zone rushes. Ole Miss ranks 25th nationally in rushing at 208.0 yards per game, and the balance keeps safeties frozen. LSU, a top-20 run defense by success rate, surrendered 87 hard yards to Lacy and still bent late. Now the Rebels face a Washington State front allowing 150.4 rushing yards per game and 4.1 per attempt, with cracks visible after travel and fatigue.

Washington State’s profile tilts toward fragility disguised as efficiency. The Cougars average 20.6 points and 306.6 total yards per game—112th nationally in scoring, 77.8 of those yards on the ground. Zevi Eckhaus brings a 64.9% completion rate, four touchdowns, and two interceptions, steady but risk-averse. He averages only 6.7 yards per attempt, and the offense rarely threatens downfield—just 5% of passes have traveled beyond 20 yards. Josh Meredith is the clear target tree: 19 catches for 255 yards and one score, most of them underneath. Kirby Vorhees has logged 156 rushing yards on 38 carries, but the line generates minimal push, creating just 1.3 yards before contact per rush. Against a Rebels defense holding opponents to 2.6 yards per carry and only 18.8 points per game, that lack of vertical or ground explosiveness is a fatal flaw.

The Cougars do bring pressure—they’ve recorded 13 sacks and rank 13th nationally in fumbles recovered—but Ole Miss’s line has allowed only five sacks in five games. Chambliss processes quickly, averaging 2.43 seconds to throw, and has taken zero sacks when rolling to his right. If Washington State sells out on heat, Lacy will feast on light boxes. This is the nightmare of playing Kiffin’s offense: every overcommitment births a mismatch, every blitz opens a seam.

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Washington State vs. Ole Miss pick, best bet

There’s a plausible counter: Ole Miss could look ahead, a noon local kickoff before Georgia and Oklahoma back-to-back. Washington State has covered in six of its last seven October games versus top-15 teams, and Lane Kiffin’s squads have occasionally drifted when favored by 30 or more. The Cougars’ defense has produced nine tackles for loss or more in three straight games and has forced a turnover in every outing. If Eckhaus stays clean and the defense limits explosives, maybe they delay the avalanche. But even that scenario depends on suppressing an offense that’s topped 40 points in three of five games and averages 530.6 total yards—322.6 through the air, 208.0 on the ground. Washington State has already given up 59 points twice. Against this kind of multiplicity, staying within four scores requires perfection.

The market sits at Ole Miss -32.5 with a total of 58.5, and the analytics paint a clearer story. Ole Miss has covered four of five games, all at home by double digits, and has a +21.8 average scoring margin. Washington State is 2–3 ATS and 1–4 straight up on the road against ranked teams since last year. Both teams trend under—Ole Miss 3–2, Washington State 3–2—but those totals mask context. The Rebels’ last two unders came against methodical SEC opponents; here, tempo should climb. Ole Miss runs 70 snaps per game and converts 50% on third down, while Washington State’s defense spends 31 minutes per game on the field. Fatigue amplifies points.

Washington State will compete until the oxygen fades. But Ole Miss at home, balanced and efficient, turns talent into inevitability.

Final score: Ole Miss 52, Washington State 17. Don’t blink. Take the points with Kiffin. I could see him fighting for the total on his own, so I like the over, here, too.

Best bet: Ole Miss -32.5 (-115) vs. Washington State

Tail it with me in the DKN Betting Group here!

Dan Johnson has been an editor, writer, and analyst for DraftKings and DraftKings Network since 2024. He’s previously held editorial posts at The Paris Review, Macmillan Publishers, Bedford/St. Martin’s Press, ASSIGNMENT Magazine, and FantasySixPack. You can find his various editorial work & writing (sports-related and non-) at all of the above.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is thegreatdansby9) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.