The Patriots Bills Parlay picks for NFL Week 5 are now available for you to check out. We’ve built the best same game parlays on DraftKings Sportsbook, combining player props, game totals, and side picks you can add to your bet slip in one tap before kickoff.
You can view our full complement of parlays and same game parlays on DraftKings Network!
Patriots vs. Bills Parlay Picks – NFL Sunday Night Football
Buffalo Bills Same Game Parlay: Back the Bills to remain undefeated with a Week 5 victory
- Buffalo Bills to Win (vs New England Patriots)
- Josh Allen 230+ Passing Yards
- James Cook 80+ Rushing Yards
- Khalil Shakir to Score a TD
Patriots-Bills Parlay: Barstool Sports’ Jon Gruden crafted up this Same Game Parlay for Patriots-Bills
- NE @ BUF: Over 49.5 Points
- TreVeyon Henderson Over 26.5 Rushing Yards
- J. Cook Under 75.5 Rushing Yards
Anytime Touchdown Same Game Parlay: Bet these players to all score a touchdown Sunday Night!
- James Cook to Score a TD
- TreVeyon Henderson to Score a TD
- Khalil Shakir to Score a TD
Josh Allen Parlay: Josh Allen has been a force through four weeks, bet the same for Week 5
- Josh Allen 330+ Pass + Rush Yards
- Josh Allen 1+ Passing TD
- Josh Allen to Score a TD
New England Patriots Parlay: Think the Patriots can pull off the upset? Back it here!
- Drake Maye 250+ Passing Yards
- Drake Maye 3+ Passing Touchdowns
- NE Patriots to Win (@ BUF)
Want even more action? Check out all of our NFL parlays on DraftKings Network for updated odds and fresh builds.
How to Watch Patriots vs. Bills
Here’s everything you need to know to watch the Week 5 primetime matchup between the New England Patriots and Buffalo Bills, including kickoff time, TV channel, and streaming options.
Date: Sunday, October 5, 2025
Location: Highmark Stadium (Orchard Park, New York)
Kickoff: 8:20 p.m. ET / 5:20 p.m. PT
TV: NBC (Sunday Night Football)
Streaming: Peacock, NBC Sports app, NFL+, and NFL Game Pass (international)
